The COVID-19 outbreak, initially identified in China, is continuing to grow more than 3 months after it was first detected in December. In the months since the novel coronavirus(SARS-CoV-2) rose from a regional crisis to a global threat, researchers and institutes large and small have scrambled to advance their ideas and efforts for the research on the drugs and vaccines. However, accurate animal models are necessary for verifying the pathogenesis and immune mechanisms of the illness thereby accelerating research across vaccine development, new drug development, gene therapy, and more. The R&D team at Cyagen has made every effort to develop animal models catered to the global SARS-CoV-2 research initiative since the COVID-19 outbreak. In order to contribute to the international epidemic prevention effort, Cyagen now provides mouse models for ACE2 and DDP4 receptor targets effectively. For consultation and order, please call 86 20-31601779 or email
● Promotion Period: March 25th 2020- April 30th 2020
● Eligibility: End clients in South Korea only
● For humanized models, knockout models, Rosa26 knockin mouse models of ACE2 and DPP4 on C57BL/6 mouse strains, the exclusive sales prices are as below:
| ACE2 / DPP4 | Service | Deliverable | Promotion Price(USD/Strain) |
|---|---|---|---|
| Knockout Mice | ≧3 F1 Heterozygotes | 3,599 | |
| Humanized Mice | 4 F1 Heterozygotes | 5,000 | |
| Knockin Mice (Rosa26) | 4 F1 Heterozygotes | 6,000 |
● In addition to ACE2 and DPP4, if you would like to order any other models related to the research of SARS-CoV-2, corroborating materials on its feasibility should be provided. Once approved by our experts, you will be offered the promotional price as well.
● Cyagen can also offer mouse models in Balb/c background, please contact us for further information.
Coronaviruses (CoV) invade human cells mainly through binding with cell membrane receptors; so far,
three membrane exopeptidases, DPP4, ACE2, and APN have been identified as entry receptors for
human-infecting coronaviruses. Among these, ACE2 is associated with the initial entry and infection of
SARS-CoV, while DPP4 is similarly linked with MERS-CoV. At present, APN is only found to relevant to
HCoV-229E infectivity, while this coronavirus does not cause severe illness. Although the human
coronavirus that combined with APN does not directly lead to lethal disease, with the same high
expression level as the receptor of MERS-CoV, it is likely to trigger severe lethal respiratory disease
like MERS once infected. Additionally, the spike protein used by coronaviruses to bind to cell surface
receptors is susceptible to mutations that alter the target receptors to enter the cell to replicate,
which can be seriously life-threatening. Therefore, Cyagen’s expert team of scientists have initiated
research and development on animal models for these three main coronavirus receptors, aiming to provide
rapid solutions for epidemic prevention research.
service-apac@cyagen.com
86 20-31601779
