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COVID-19 Epidemic Prevention Exclusive ACE2 & DPP4 Mouse Models Ordering Now Available!
The COVID-19 outbreak, initially identified in China, is continuing to grow more than 3 months after it was first detected in December. In the months since the novel coronavirus(SARS-CoV-2) rose from a regional crisis to a global threat, researchers and institutes large and small have scrambled to advance their ideas and efforts for the research on the drugs and vaccines. However, accurate animal models are necessary for verifying the pathogenesis and immune mechanisms of the illness thereby accelerating research across vaccine development, new drug development, gene therapy, and more. The R&D team at Cyagen has made every effort to develop animal models catered to the global SARS-CoV-2 research initiative since the COVID-19 outbreak. In order to contribute to the international epidemic prevention effort, Cyagen now provides mouse models for ACE2 and DDP4 receptor targets effectively. For consultation and order, please call 86 20-31601779 or email
COVID-19 ACE2 & DPP4 animal models are NOW available to order!
● Promotion Period: March 25th 2020- April 30th 2020
● Eligibility: End clients in South Korea only

For humanized models, knockout models, Rosa26 knockin mouse models of ACE2 and DPP4 on C57BL/6 mouse strains, the exclusive sales prices are as below:

ACE2 / DPP4 Service Deliverable Promotion Price(USD/Strain)
Knockout Mice ≧3 F1 Heterozygotes 3,599
Humanized Mice 4 F1 Heterozygotes 5,000
Knockin Mice (Rosa26) 4 F1 Heterozygotes 6,000

In addition to ACE2 and DPP4, if you would like to order any other models related to the research of SARS-CoV-2, corroborating materials on its feasibility should be provided. Once approved by our experts, you will be offered the promotional price as well.

Cyagen can also offer mouse models in Balb/c background, please contact us for further information.

Why ACE2, DPP4 and APN?
Coronaviruses (CoV) invade human cells mainly through binding with cell membrane receptors; so far, three membrane exopeptidases, DPP4, ACE2, and APN have been identified as entry receptors for human-infecting coronaviruses. Among these, ACE2 is associated with the initial entry and infection of SARS-CoV, while DPP4 is similarly linked with MERS-CoV. At present, APN is only found to relevant to HCoV-229E infectivity, while this coronavirus does not cause severe illness. Although the human coronavirus that combined with APN does not directly lead to lethal disease, with the same high expression level as the receptor of MERS-CoV, it is likely to trigger severe lethal respiratory disease like MERS once infected. Additionally, the spike protein used by coronaviruses to bind to cell surface receptors is susceptible to mutations that alter the target receptors to enter the cell to replicate, which can be seriously life-threatening. Therefore, Cyagen’s expert team of scientists have initiated research and development on animal models for these three main coronavirus receptors, aiming to provide rapid solutions for epidemic prevention research.
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Cyagen Advantages

Well-Established Platform

Lead by internationally renowned Cyagen scientists, 14-years’ experience, successfully-developed over 10,000 mouse model projects mature and stable operation platform

Professional Technical Support

Cyagen's project management team will reasonably control the process quality in accordance with your preference or requirements. We provide you with an experimental scheme as well as up-to-date project reports and post-delivery consultation services, helping to minimize both your time and energy spent managing the project.

AAALAC-Accredited and OLAW Assured

The Cyagen Transgenic Animal Center (CTAC) is AAALAC-accredited and OLAW assured - demonstrating Cyagen's adherence to strict guidelines for the care and use of animals.

World-Class Facilities

Specific-pathogen-free (SPF) animal health status and strict adherence to protocol provides more reliable experimental statistics. To ensure the efficient operation of the animal room, our center is equipped with medical ground sterilizers, automatic cage cleaning machines, ozone and ultraviolet (UV) disinfection facility, automatic waste collection, and odor removal systems.
Reverse Erythroblastosis Virus α Antagonism Promotes Homocysteine Catabolism and Ammonia Clearance.
Hepatology (2019) PMID: 31016736
Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation.
Nucleic Acids Res (2019) PMID: 31037292
AQP4ex is crucial for the anchoring of AQP4 at the astrocyte end-feet and for neuromyelitis optica antibody binding.
Acta Neuropathol Commun (2019); 7(1): 51
VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages.
Science Advances (2019) DOI: 10.1126/sciadv.aau7426