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Congenital immunodeficient mice are the most widely used in scientific research studies, they are usually applied as laboratory animals for tumor models. Common examples of congenitally immunodeficient backgrounds include Nude mice, severe combined immunodeficient (SCID) mice, NOD SCID mice, among others.
| Immunodeficient Mice | Research and Application |
|---|---|
| BALB/c nude Mice | Nude mice are ideal hosts for rapidly growing tumor cells because they are hairless and easy to observe and count tumor growth. However, they are not suitable hosts for lymphoma and leukemia studies because they retain B cells and strong NK cell responses. |
| NOD SCID Mouse | Immunodeficient mice lacking both T and B lymphocytes. Multiple immunological defects unique to this model provide an excellent system for reconstitution with human hematopoietic cells, resulting in exceptional models for HIV-1 research and gene therapy. |
| C-NKG Mice | NKG mouse lacks mature T, B and NK immune cells, so the complement activity is reduced and macrophage phagocytosis of human derived cells is weak. This model can efficiently transplant hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), patient-derived xenograft (PDX) or adult stem cells and tissues, which is recognized as having high degree of immune deficiency and has good performance in the study of tumor, immunity, autoimmunity diseases, immunotherapy vaccine, GVHD/transplantation, safety evaluation, etc. |