Knockout Mouse Catalog | Cyagen APAC

Compound Model - NAFLD Mouse Model

Request a Quote or Information
Our Experts will contact you providing a quote,
information and estimated timeframe to
your project needs.

 

Many researchers have combined the genetic modification model with diet or drug induction to produce a composite model, which makes the phenotype and pathogenesis of the model closer to that of human NAFLD. Composite models can more accurately reflect the progression of the disease development - from simple fatty liver to NASH, and progression to liver fibrosis.

The Most Commonly Used Composite Models: ob/ob mice + methionine-choline deficient (MCD) diet; db/db mice + methionine choline deficient (MCD) diet, Zucker rats + methionine choline deficient (MCD) diet/high fat diet.

The 'db/db mouse + MCD diet' model is more severe than the 'ob/ob mouse + MCD diet' model in both inflammation and fibrosis around the cells, and also demonstrates a significantly shortened induction period - which has led to predominate use of the 'db/db mouse + MCD diet' model.

Detection Items: body weight, food intake, serum biochemical test (alanine aminotransferase, aspartate aminotransferase, serum total cholesterol, triglyceride content, etc.), pathological analysis of liver tissue (liver tissue H & E staining, oil red).

Why work with Cyagen?

  • 14+ years' experience in custom animal model generation
  • 78,000+ animal models generated and delivered worldwide
  • 4,700+ citations in SCI journals for our services
  • 3,000+ university and company partners
  • 100% money-back guarantee option available for most services
  • AAALAC-Accredited and OLAW Assured
For business development and collaboration opportunities, please contact us:

Your Name can not be empty

Please enter a valid phone number.

Your Phone can not be empty

Your Country can not be empty

Institution/Affiliation can not be empty

Please enter a valid email address.

Your Email can not be empty

The content can not be empty