Weekly Flash Sales - Live KO & cKO Mice

As the popularity of our Cyagen AI Knockout Mouse Model eBank has rapidly grown, we want to promote accessibility of these models to more researchers. To support this goal, we are now offering limited stocks of select knockout (KO) mouse models to researchers at a significant savings and with expedited delivery.

Cyagen’s Weekly Flash Sales for Knockout Models will provide a list of specific gene knockout (KO) mice that are available until the “off-the-shelf date” at a substantial discount. For consultation and order, please call 86 20-31601779 or email service-apac@cyagen.com.

Eligibility: End clients in Asia Pacific region, excluding Japan.

Eligible Products	Promotion Price
Knockout Catalog Models	$999/mouse
Conditional Knockout Catalog Models	$1,899/mouse

Search the Flash Sale for Your Gene

September 26^th - September 30^th
Gene Name	NCBI Gene ID	Project Type	Strain Background	Application Field	Off the Shelf Date	Order Now

Note:

Check back regularly for our updated listings of KO/cKO mice available at a savings – your gene of interest could be included next!

Dear Researcher,
The gene you desire is not listed in the Weekly Flash Sales Event. You can click following details to get cryopreserved strains. Please email us at service-apac@cyagen.com if any questions.

Applications for KO Mice

	Studies of gene function Absence of gene activity can elucidate the biological roles of a gene and its potential participation in pathogenesis of human disease. Providing in vivo data on the mechanism of action (MOA) can improve the significance of your publications and even expedite results.

	Target discovery and confirmation Data from in vitro experiments are not reliable enough on their own; in vivo data is required to validate the target for a successful drug development program.

	Verifying compound specificity The primary cause of drug failures is attributed to non-specificity, which may cause dangerous off-target effects. KO models can remove a functional protein target, providing an in vivo system to detect potential off-target effects of an antagonist.

Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline.

Cell Metabolism PMID: 32004475 (2020) PMID: 32004475

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Nature Nanotechnology (2020) PMID: 32123380

Targeting Degradation of the Transcription Factor C/EBPb Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages.

Immunity (2019) 51: 522

Inhibition of S-Adenosyl homocysteineHydrolase Induces Endothelial Dysfunction via Epigenetic Regulation of p66shc-Mediated Oxidative Stress Pathway.

Circulation (2019) 139: 2260

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