Knockout Mouse Catalog | Cyagen APAC

Animal Surgical & Disease Model Services

Overview: Cyagen Small Animal Surgical & Disease Model Services

In view of this situation, Cyagen has utilized years’ of accumulated experience in efficient team building and management to successfully build a mature mouse surgical model service team after 2 years’ preparation. Cyagen’s team has developed rigorous standards in the production and construction of various models - establishing complex and compound surgical disease models. We take “Repeatable” as our service standard. For complex project requirements or disease models not or rarely seen in the literature, we will work closely with clients to carefully understand their research needs and develop the appropriate surgical model construction scheme. We truly hope our professionally-standardized surgical model services will save your time and energy - enabling you to achieve results on innovative research project(s).

Our Advantages

  • 1. Take “Repeatable”as the service standard
    We take “Repeatable” as our gold standard: our technical team is thoroughly trained in surgical model operations to ensure the data stability of every model, even across different batches.
  • 2. One-stop service: Save time and energy
    Some custom animal models require a combination of gene modification, surgical modelling, and physical stimulation/drug induction to achieve the desired phenotype. Our professional surgical model team works with our highly-developed genome-editing, breeding, and cryopreservation platforms to accomplish the most complicated model generation projects. Cyagen provides a one-stop service for all your small animal model generation and support needs, including: "Genome-editing Mouse Model Construction/Generation - Population Propagation - Surgical Modelling - Phenotypic Validation” - saving you time and energy.
  • 3. Professional Technical Support
    Cyagen’s small animal surgical team are skilled across various model generation techniques, including complex and compound surgical disease model establishment. We provide technical information throughout the process to cater to your needs, from model generation proposals and up-to-date project reports, all the way to after-sales services – ensuring that you have everything you need for experimental success.
  • 4. Complying to international animal welfare and quality standards with double accreditation of AAALAC and ISO9001: 2015
    The Cyagen Transgenic Animal Center (CTAC) has passed the double accreditation of ISO9001:2015 and AAALAC. All of our products and technical services provided to experts and scientists consistently meet the international standards for quality, as signified by ISO9001:2015. Our AAALAC accreditation demonstrates that Cyagen Biosciences upholds respectful practices in animal welfare and ethics as part of our rigorous bio-safety standards.
Animal species applicable: Mouse and Rat

Chief Scientist of Cyagen Surgical Disease Models

Dr. Rongli Zhang
Dr. Rongli Zhang has more than 20 years of experience in creating mouse surgical models. Prior to Cyagen, Dr. Zhang was employed by China Academy of Chinese Medical Science (CACMS), Tsinghua University (THU), Peking University (PKU) and internationally renowned academic institutions successively after PhD. He worked in Case Western Reserve University in U.S since 2011 as both a research scientist and director of Cardiovascular Physiology Laboratory, in charge of the discovery of disease phenotype in genetically engineered animals and preclinical drug development.

In addition, he has done many preclinical pharmacology studies for famous domestic and worldwide pharmaceutical enterprises - helping these companies achieve successful product launches. Dr. Zhang has finished 10 projects during his work in China, and took part in multiple fund programs in the U.S. supported by both the NIH (National Institutes of Health) and AHA (American Heart Association). He has 60 publications in SCI journals, with many articles published in high-impact academic journals (such as Nature, Proceedings of the National Academy of Sciences, Journal of Clinical Investigation, Circulation, Cell, Nature Communications, and Science Translational Medicine).

Case Study

1. Myocardial Infarction Model (Left Coronary Artery Ligation), Ischemia/Reperfusion Model (MIRI)

2. Transverse Aortic Constriction (TAC)

3. Chronic Heart Failure (CHF)

Cardiovascular and Cerebrovascular Disease Models Myocardial Infarction Model (Left Coronary Artery Ligation)
Ischemia/Reperfusion Model
Transverse Aortic Constriction
Ascending Aortic Constriction
Abdominal Aortic Constriction,Hypertension Model
Heart Failure Model
Pulmonary Artery Hypertension Model
Middle Cerebral Artery Occlusion Model
Femoral Artery Endothelial Injury Model,Femoral Wire Injury Model
Carotid Artery Ligation
Deep Vein Thrombosis Model
Hind-limb Ischemia Model
Portal Caval Shunt
Left and Right Ventricular Hemodynamic Study Left Ventricular Hemodynamics Study
Right Ventricular Hemodynamics Study
Abdominal Surgery Bile Duct Ligation
Vertical Sleeve Gastrectomy
Partial Small Intestine Resection
Unilateral Nephrectomy
3/4 Nephrectomy
5/6 Nephrectomy
Adrenal Demodulation
Osteoarthritis Model (MIA)
Splenic Denervation
Stomach Vagotomy
Unilateral or Bilateral Tubal Ligation
Ureter Ligation
Neurological Surgery Unilateral Brain Cannulation
Bilateral Brain Cannulation
Intralateral Ventricular Cannulation
Intralateral Ventricular Cannulation for Pump Connection
The 3rd Ventricular Brain Cannulation
Gastrocnemius Neurotomy
Soft Tissue Surgery Thymectomy
Telemetry Transducer Implantation Surgery Blood Pressure Telemetry
Left Ventricle Pressure Telemetry
Portal Vein Pressure Telemetry
Blood Pressure and Electrocardiograph Telemetry
Blood Pressure and Electroencephalograph Telemetry
Pleural Pressure Telemetry
Pleural Pressure and Electrocardiograph Telemetry
Electrocardiograph Telemetry
Electroencephalograph Telemetry
Electromyograph Telemetry
Electrocardiograph and Electroencephalograph Telemetry
Electroencephalograph and Electromyograph Telemetry
Blood Glucose Telemetry
Temperature and Activity Telemetry
Vascular Catheter Surgery Common Carotid Artery Catheter
Common Carotid Artery Catheter – Cranial Dosing
Abdominal Artery Catheter
Femoral Artery Catheter
Femoral Vein Catheter
Jugular Vein Catheter
Double Jugular Vein Catheter
Portal Vein Catheter
Inferior Vena Cava Catheter
Non-Vascular Catheter Surgery Bile Duct Catheter
Stomach Catheter
Duodenal Catheter
Jejunum Catheter
Ileum Catheter
Cecum Catheter
Colon Catheter
Urinary Bladder Catheter
Intraperitoneal Catheter
Subcutaneous Catheter
Intrathecal Catheter
Bone Marrow Transplantation, Cell Transplantation Bone Marrow Transplantation
Cell Transplantation
Cancer Graft Models Subcutaneous Tumor Model
In Situ Carcinoma Model
Patient-Derived Tumor Xenograft (PDX) Model
Infusion Pumps Implantation Surgery Infusion Pumps Implantation Surgery
Animal Dosing – Drug, Virus, and Plasmid Injections Vein Injection - Neonatal
Ocular Vein Injection
Tail Vein Injection
Intraperitoneal Injection
Subcutaneous Injection
Intradermal Injection
Intraventricular Injection
Special Injection Methods
Blood Sample and Specimen Collection Inferior Vena Cava Blood Sampling
Left Ventricular Blood Sampling
Right Ventricular Blood Sampling
Tail Vein Blood Sampling
Ocular Vein Blood Sampling
Facial Vein Blood Sampling
Organ or Tissue Sampling
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