Cyagen provides mouse and rat cardiovascular and cerebrovascular disease model services performed entirely within our AAALAC-accredited facilities. Our efficient small animal surgical team can provide you with animal surgical models for basic or preclinical research. For more information about the selection of animals, specific surgical techniques, preoperative and postoperative examination and evaluation methods, and compound surgical procedures that can be operated on the same animal (such as implanted sensor, micro infusion pump, arterial or venous catheter) and other special requirements, please contact our sales representatives for custom solution schemes and pricing.
Animal species applicable: Mouse and Rat
Introduction:
1.The Myocardial Infarction Model is achieved by permanent ligation of left coronary artery.
2.Ischemia/Reperfusion Model is achieved by reperfusion of left coronary artery after a certain time of Ischemia
Applications: Drug testing, biomedical research, acute (a few hours to several days) and chronic (a few weeks to several months) experiments
Animal species applicable: Mouse and Rat
Introduction: Quantitative constriction of the transverse aortic results in the obstruction of aortic blood flow, increased indoor pressure, hyperplasia and Left Ventricular Hypertrophy (LVH), and heart failure.
Applications: Drug testing, biomedical research, acute and chronic experiments
Animal species applicable: Mouse and Rat
Introduction: Quantitative constriction of ascending aorta results in the obstruction of aortic blood flow, increased indoor pressure, hyperplasia and hypertrophy of the left ventricular, and heart failure.
Applications: Drug testing, biomedical research, acute and chronic experiments
Animal species applicable: Mouse and Rat
Introduction: Quantitative constriction of the abdominal aorta results in the obstruction of abdominal aortic blood flow, increased blood pressure, hyperplasia and hypertrophy of the left ventricle.
Applications: Drug testing, biomedical research, acute and chronic experiments
Animal species applicable: Mouse and Rat
Introduction: Left heart failure model is achieved by myocardial infarction or left ventricular hypertrophy (LVH).
Applications: Drug testing, biomedical research, acute and chronic experiments
Animal species applicable: Mouse and Rat
Introduction: Pulmonary hypertension model is achieved by chronic hypoxia.
Applications: Drug testing, biomedical research, and chronic experiments
Animal species applicable: Mouse and Rat
Introduction: Blocking the blood flow of unilateral middle cerebral artery at a fixed point results in unilateral middle cerebral artery embolism (or ischemia-reperfusion injury) and unilateral limb activity limitation.
Applications: Drug testing, biomedical research, acute and chronic experiments
Animal species applicable: Mouse and Rat
Introduction: Femoral artery endothelial cells are injured by wire to evaluate the degree of intimal hyperplasia or vascular inflammatory response.
Applications: Drug testing, biomedical research, and chronic experiments
Animal species applicable: Mouse and Rat
Introduction: This model is achieved by complete or partial ligation of unilateral carotid artery to evaluate the degree of intimal hyperplasia hemodynamic changes.
Applications: Drug testing, biomedical research, and chronic experiments
Animal species applicable: Mouse and Rat
Introduction: This model is achieved by vein thrombosis in the specific site of inferior vena cava.
Applications: Drug testing, biomedical research, acute and chronic experiments
Animal species applicable: Mouse and Rat
Introduction: Hind-limb ischemia model is achieved by femoral artery ligation.
Applications: Drug testing, biomedical research, and chronic experiments
Animal species applicable: Rat
Introduction: This model is achieved by anastomosis of portal vein with inferior vena cava.
Applications: Drug testing, biomedical research, and chronic experiments