Knockout Mouse Catalog | Cyagen APAC

Knockout Mice

A knockout mouse is a genetically modified mouse in which researchers have inactivated, or knockout out, an existing gene by replacing it or disrupting it with an artificial piece of DNA. Cyagen offers a one-stop solution for all your gene targeting mouse model needs. Our knockout services include conventional knockout and conditional knockout. You can contract us to perform your entire targeting project from initial strategy design and targeting vector construction to mutant animal delivery, or you can outsource specific phases of the project to us.
◆ Cyagen Knockout Mouse Model Solution

1. ESC-based Gene Targeting - TurboKnockout ®

TurboKnockout ®, the newest ES-cell based gene targeting technology which eliminates two generations of breeding, allowing the generation of conditional knockout mouse models in as fast as 6 months, 4-6 months shorter than the standard approaches.

Highlights of TurboKnockout ®:

  • Timeline comparable to nuclease-based genome editing (i.e., CRISPR, TALEN)
  • More reliable than nuclease mediated methods (e.g., conditional models, humanizations)
  • Guaranteed germline transmission
  • No off-target effects
  • Comparable cost to traditional ES cell methods

2. CRISPR/Cas-based Knockout Mice

Genome editing using CRISPR/Cas system can generate constitutive knockout founder animals in as little as 3 months.



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