Advancing Neurodegenerative Disease Research with Animal Models
One-Stop Solution
Model Construction | Model Processing | Behavioral Experiments | Phenotypic Analysis
Neurodegenerative diseases are a heterogeneous group of disorders characterized by the nerve cells in the brain or peripheral nervous system lose function and even die ultimately. The most common neurodegenerative diseases include Alzheimer's disease and Parkinson's disease. At present, there are no effective cures or treatments for most neurodegenerative diseases, and even drugs that can slow the course of the disease are very scarce.
The study of neurodegenerative diseases is a holistic process, from the initial model construction to injection and evaluation at the cellular level (in vitro) and animal level (in vivo), to behavioral experiments, and phenotypic analysis, eventually forming a complete research logic. In brief, if the target site or target protein has been identified, the general experimental workflow for neurodegenerative disease research is as follows:
With more than 15 years’ experience in genetic engineering, Cyagen has completed its one-stop research solutions to offer a range of products and services supporting the advancement of neurological and neurodegenerative disease research - from custom rodent model generation and breeding, through therapeutic viral packaging and injection, and phenotype analysis to study disease mechanisms, target validation, drug screening and more.
Contact Our Experts for Assistance on Neurodegenerative Disease Research >>
Developing precise animal models can provide researchers key information on neurodegenerative disease mechanisms and potential treatment approaches - supporting efficient drug development for neurodegenerative diseases. In addition, in vitro approaches have been used commonly to understand the etiology and pathogenesis of a broad range of neurodegenerative diseases.
To better cater to research needs, Cyagen is now providing both in vivo (animal) and in vitro (cell) experimental models, as well as research model support services for constructing experimental models for neuroscience studies thoroughly:
| Service Type | Service Detail |
|---|---|
| Genetically Engineered Mouse or Rat Models | Knockout, Knockin, Conditional knockout, Point mutation, and more |
| Reay-to-use KO/cKO Mouse Models |
● Over 16,000 custom KO and cKO/floxed strains ● 3,000 live mice are available to researchers in as few as 2 weeks |
| Drug Evaluation Disease Models | Metabolic models, CDX models, Immunodeficient mice, Humanized immune checkpoint mice, and more |
| Custom Cell Line Services | Knockout, Knockin, Overexpression, Point mutations |
| Stem Cells | Neural stem cells, and other |
Contact us with your project details to request your model generation strategy.
According to statistics from the numerous research papers published in the three major journals of neurobiology (Neuron, Nature Neuroscience, Journal of Neuroscience), mice account for the highest proportion among the genetically modified models in the model selection. Additionally, methods such as immunofluorescence histochemistry, ethology, and viral transfection/tracing are of utmost importance in animal model studies.
Cyagen is able to provide highly customized phenotype analysis and supplmentary services to meet your needs.
| Service Type | Service Detail |
|---|---|
| Research Model Support Services |
● Vector construction ● Virus packaging ● Breeding or Cryopreservation ● Animal surgical and disease model services |
|
Phenotype Analyasis ● Ultrasonography ● Blood Biochemistry ● Histology & Pathology ● Metabolic Phenotyping ● Gene and Protein Expression ● Cell Function Testing |
Contact us with your project details to request your phenotype analyasis service.
1. Reviews on Common Neurodegenerative Diseases and Research Models
In under 15 years since its founding, Cyagen has become a leading provider of custom mouse and rat models – delivering over 78,400 models to researchers worldwide and receiving over 4,800 peer-reviewed citations. From strategy design through to delivery of research-ready custom models, Cyagen offers complete outsourcing for all your animal model needs. We can create any custom mouse or rat model with guaranteed genotype validation, even offering phenotypic characterization and other downstream services required to your needs on neurodegenerative disease research.
1. Complete research solutions - from custom rodent model generation to therapeutic viral
packaging and injection.
2. Both in vivo (animal) or in vitro (cell) experimental models available.
3. Expert scientific team provides in-depth technical support and assistance in formulating
research model strategies.
If you are engaged with or interested in neurodegenerative disease research, Cyagen's experts can provide you with in-depth technical support and discuss your project plans. We also provide customize model generation strategies, helping develop your neuroscience research and publish high-impact articles.
Contact us with your project details to request your complimentary model generation project consultation, strategy, and quote.
Cyagen AI Knockout Mouse Model eBank
Over 16,000 knockout (KO) /conditional knockout (cKO) mouse models are available from the Cyagen AI Knockout Mouse Model eBank with the following advantages compared to other mouse model repositories:
● Reduced Risk: Validated genome, guaranteed models
● Skip Backcrossing: 100% pure C57BL/6 background
● Fast Turnaround: 3,000 live strains, delivered as fast as
2 weeks
Efficient and intelligent Model Customization Platform
Cyagen's TurboKnockout® Gene Targeting service eliminates two generations of breeding, providing founder mice in as fast as 6 months. CRISPR-based Rapid Knockout services enable up to 500kb knockout (KO) and up to 15kb knockin (KI). From rigorous personnel training, health testing, and genetic control, to personalized breeding and preservation, Cyagen's comprehensive capabilities can meet your every need for customized animal models.
Drug Screening and Assessment Mouse Model Platform
To help domestic researchers easily obtain the highest-quality animal models of disease, Cyagen has established its own drug research and development product line through a combination of self-research and introduction – to serve drug discovery and screening in the fields of cancer, immunity, endocrinology, cardiovasology, neurology, infectious diseases, and more. We are able to provide genetically modified tumor mouse/rat models, Immunodeficient mice, syngeneic model, human tumor cell line xenotransplantation (CDX) model, mice with reconstituted human immune system, immune checkpoint (ICP) humanized mice, models for metabolic disease and drug efficacy evaluations - including obesity, atherosclerosis, diabetes, non-alcoholic fatty liver disease (NAFLD), and more.
One-Stop Small Animal Phenotype Analysis Platform
Cyagen's one-stop small animal phenotype analysis platform can provide standardized phenotyping services covering cardiovascular, tumor, immunity, metabolism, nerve, and other fields. Services include surgical model construction and analysis of blood, tissue histology and morphology, pathology, gene and protein expression, behavioral and metabolic analytics, and more. To provide customers with a complete and systematic service platform, the intermediate work such as model construction, breeding, surgery, model and phenotype analysis are all undertaken by Cyagen – delivering the comprehensive results and final report for use in your study.
Custom Cell Line Services
Cyagen can provide various types of custom cell line services such as vector construction, virus packaging and over expression, interference, gene knockout cell line, point mutation cell line and gene knockin cell line. Leverage our experts and optimized CRISPR/Cas9 cell line modeling service platform CRISPR-Pro for a hassle-free research. CRISPR-Pro enables large fragments excision or correct mutations in various cell lines.