Alongside the aging of society and the prevalence of obesity, the incidence of metabolic diseases is increasing yearly - which is a serious threat to human health. The most common metabolic diseases include obesity, type 2 diabetes caused by insulin resistance, and non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH).
Obesity is a metabolic disorder affected by numerous factors such as diet, environment, genetics, etc - which is the main cause of many chronic diseases. Animal models are essential tools for further understanding of the pathogenesis of obesity and exploring effective treatment methods. At present, animal models of obesity are mainly divided into four categories: diet-induced obesity, hypothalamic obesity, obesity caused by endocrine disorders, and genetic contributors. The diet-induced animal obesity (DIO) model recapitulates metabolic factors implicated in human obesity, which has led to its use in studying the relationship between diet, genes, and other factors in the developmental process of obesity, diabetes, and related metabolic disorders.
Cyagen can provide you with various obesity mouse models and phenotype analysis services - please contact us for a custom project quote.
Diet-induced obesity (DIO) Model
☞ Click here to learn more about DIO mouse models.
Diabetes mellitus (DM), commonly known as diabetes, a syndrome composed of acute and chronic hyperglycemia with obvious heterogeneity and its complications, caused by genetic, environmental, immune, and other factors. Diabetes has become the third leading chronic disease threatening human health, following cancer and cardiovascular disease (CVD). The American Diabetes Association (ADA) has divided diabetes into four types: type I diabetes (T1DM), type II diabetes (T2DM), other special diabetes, and gestational diabetes. Diabetes mellitus (DM) animal models play an important role in the study of diabetes mellitus and are generally categorized into spontaneous, induced, and genetically engineered models.
Cyagen can provide you with various obesity diabetes mellitus mouse models and phenotype analysis services - please contact us for a custom project quote.
a. Type 2 Diabetes Mellitus (T2DM) Mouse Model
☞ Click here to learn more about T2DM mouse models.
b. Type 1 Diabetes Mellitus (T1DM) Mouse Model
☞ Click here to learn more about T1DM mouse models.
Non-alcoholic fatty liver disease (NAFLD), a hepatopathy syndrome affecting both adults and children, is characterized by a range of liver conditions affecting people who consume little to no alcohol, including simple fatty liver, steatohepatitis, fatty liver fibrosis, and cirrhosis. NAFLD can progress from simple fatty liver through nonalcoholic steatohepatitis (NASH) to liver fibrosis, and even lead to end-stage liver diseases, such as, liver cirrhosis, hepatocellular carcinoma (HCC), or liver failure. Animal models play an important role in elucidating the pathophysiological mechanisms of non-alcoholic fatty liver disease (NAFLD) and the development of new drugs. Preclinical studies require the application of different animal models based on the specific NAFLD phenotype being studied. The preclinical animal models of NAFLD and NASH can be divided into four categories: diet-induced models, chemically induced models, genetically modified models, and composite (combined) models.
Cyagen can provide you with various Non-alcoholic Fatty Liver Disease (NAFLD) mouse models and phenotype analysis services - please contact us for a custom project quote.
a. Diet-induced Non-alcoholic Fatty Liver Disease (NAFLD) Mouse Model
☞ Click here to learn more about Diet-induced NALFD mouse models.
b. Chemical-induced Non-alcoholic Fatty Liver Disease (NAFLD) Mouse Model
☞ Click here to learn more about Chemical-induced NAFLD mouse models.
c. Non-alcoholic Fatty Liver Disease (NAFLD) Mouse Model (Gene-editing)
☞ Click here to learn more about genetically modified NAFLD mouse models.
d. Composite (combined) Model - Non-alcoholic Fatty Liver Disease (NAFLD) Model
☞ Click here to learn more about composite NAFLD mouse models.
Cardiovascular diseases (CVDs) are the leading cause of death across the globe, with Atherosclerosis (AS) serving as the common pathological basis of common cardiovascular and cerebrovascular diseases. Atherosclerosis refers to the thickening and hardening of the arterial wall and narrowing of the vascular lumen, caused by depositions of fat, thrombus, connective tissue, and calcium carbonate in blood vessels. Once these plaques have significantly narrowed, or completely blocked, the arterial lumen, the tissues and organs supplied by the artery will develop ischemia or necrosis. The use of animal models of atherosclerosis (AS) is an essential tool to study the occurrence, development, and treatment of cardiovascular diseases. At present, the commonly used modeling techniques including feeding, gavage, injection, mechanical injury, immune injury, and genetic modification.
Cyagen can provide you with various atherosclerosis mouse models and phenotype analysis services - please contact us for a custom project quote.
a. Composite (combined) Model - Atherosclerosis Mouse Model
☞ Click here to learn more
b. Atherosclerosis Mouse Model (Gene-editing)
☞ Click here to learn more
Pancreatitis is one of the major diseases that seriously affect the health and quality of life of people, which can be divided into acute pancreatitis and chronic pancreatitis according to the pathological process of this disease. Animal models of pancreatitis have played an important role in studying the pathogenesis of pancreatitis and exploring clinical treatment options. There are many methods for preparing pancreatitis animal models, with the injection of sodium taurocholate into the pancreatic duct being a more commonly used method.
Cyagen can provide you with various pancreatitis mouse models and phenotype analysis services - please contact us for a custom project quote.
a. Acute Pancreatitis Mouse Model
☞ Click here to learn more
b. Chronic Pancreatitis Mouse Model
☞ Click here to learn more