BALB/c nude Mouse

Model Description

Background: BALB/c nude

Features:

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  Inbred mouse strain
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  Foxn1^nu mutation leads to abnormal hair growth and defective development of thymic epithelium
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  Lack of mature T lymphocytes
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Phenotypic information:

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  Homozygous mice is athymic and hairless. The lack of T cells makes the mice permissive to allografts and xenografts.
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  Heterozygous mice have hair, and them were initially thought to possess a normal immune system. However, in fact, they have defective immunity, such as decreased number of bone marrow stem cells and reduced weight of thymus. Thus, they may not be suitable for use as sentinels, but hey can be used in PK/PD studies.
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Applications:

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  Allografts and xenografts, for example, evaluation of the proliferation, metastasis and invasion ability of tumor cells, and the efficacy of anti-cancer therapy
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  Immunology and Genetics
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  Infection mechanism of viruses, bacteria and parasites
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  Skin diseases and microbiology
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  Endocrinology and Geriatrics

Model Validation

 

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  CDX

 

Figure 1. Kinetics of Tumor growth and body weight in mice bearing HGC-27 gastric carcinoma. 5×10⁶ or 1×10⁷ HGC-27 human gastric carcinoma cells were injected subcutaneously into BALB/c nude mice. Tumor volume (Figure A) and body weight (Figure B) were measured at different time points.

 

*For more validation data please contact us.

Model Resources

 

Digital Resources: 

BALB/c nude Mouse

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Mouse Models for

Drug Screening & Assessment

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Cyagen Animal Models

Catalog - 2021

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Why work with Cyagen?

With more than 15 years’ experience in genetic engineering, Cyagen offers a complete range of products and services to support the advancement of human disease research. Cyagen is committed to enabling the development of therapeutics for human diseases by providing one-stop research solutions – from custom rodent model generation and breeding, through therapeutic viral packaging and injection, and phenotype analysis to study disease mechanisms, target validation, drug screening and more.

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  14+ years' experience in custom animal model generation
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  78,000+ animal models generated and delivered worldwide
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  4,800+ citations in SCI journals for our services
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  3,000+ university and company partners
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  100% money-back guarantee option available for most services
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*If you require any further information, please contact us.