Knockout Mouse Catalog | Cyagen APAC

T1DM Mouse Model

Request a Quote or Information
Our Experts will contact you providing a quote,
information and estimated timeframe to
your project needs.


Diabetes Mellitus (DM) has become the top third major chronic disease threatening human health after cancer and cardiovascular disease. This chronic disease is diagnosed when the body cannot secrete sufficient insulin or the insulin produced does not work effectively, resulting in increased glucose levels. Type 1 diabetes mellitus (T1DM) accounts for about 10% of all diabetic patients. The most used T1DM models are as follows:

1. Spontaneous Type 1 Diabetes (T1DM) Model

The non-obese diabetic (NOD) mouse spontaneously develops type 1 diabetes (T1D). The symptoms are similar to those of human diabetes, including phenotype such as hyperglycemia, diabetes, polydipsia, polyuria, etc. Animals with type 1 diabetes will die within 1-2 months due to ketonemia without exogenous insulin treatment. The incidence of diabetes in female NOD mice is higher than that in male mice.


2. Induced Type 1 diabetes (T1DM) Model

The type 1 diabetes model (T1DM) induced by streptozotocin (STZ) in rats and mice has many similarities with human type 1 diabetes in clinical manifestations, course of the disease, and morphological changes of the pancreatic islet. Streptozotocin (STZ) is currently the most widely used chemical inducer for animal models of diabetes, which has a specific damaging effect on animal pancreatic islet B cells. Taking advantage of this feature, high-dose streptozotocin (STZ) was used to induce animal pancreatic islet B cell necrosis and develop type I diabetes. The construction of the STZ-induced type 1 diabetes model has the advantages of simple operation, selective damage to pancreatic islet B cells, and low drug toxicity under the dosage.

Test items: Body weight, food intake, glucose tolerance test (GTT), insulin tolerance test (ITT), fasting blood glucose test, random blood glucose test, serum biochemical test or kit method (ELISA test kit), physiological cage test (urine and feces collection), metabolic cage detection (indicators such as oxygen consumption, heat production, activity, etc.), tissue and organ collection and pathology analysis (H&E, Sirius red, Masson, Oil red, IHC, etc.), etc.


3. Type 1 Diabetes - Related genetically engineered mouse model

Why work with Cyagen?

  • 14+ years' experience in custom animal model generation
  • 78,000+ animal models generated and delivered worldwide
  • 4,700+ citations in SCI journals for our services
  • 3,000+ university and company partners
  • 100% money-back guarantee option available for most services
  • AAALAC-Accredited and OLAW Assured
For business development and collaboration opportunities, please contact us:

Your Name can not be empty

Please enter a valid phone number.

Your Phone can not be empty

Your Country can not be empty

Institution/Affiliation can not be empty

Please enter a valid email address.

Your Email can not be empty

The content can not be empty