Knockout Mouse Catalog | Cyagen APAC

Ophthalmic Disease Models

In recent years, significant progress has been made in understanding the genetic factors underlying various ophthalmic diseases. The development of relevant animal models has played a crucial role in advancing preclinical research, including the study of disease mechanisms, drug target identification, and evaluation of treatment efficacy.


Cyagen has created a series of gene-edited models for ophthalmic diseases, such as Leber Congenital Amaurosis 2 (LCA2), Leber Congenital Amaurosis 10 (LCA10), retinitis pigmentosa, retinal degeneration, age-related macular degeneration, and corneal endothelial dysfunction. These models exhibit well-defined phenotypic characteristics and offer stable and heritable genetic traits, making them valuable tools for various ophthalmology-related investigations.


Additionally, Cyagen provides a specialized platform for ophthalmic pharmacology analysis. This comprehensive service covers ocular drug administration, in vivo ocular detection, ocular tissue collection, histological analysis, and gene and protein expression detection, ensuring integrate evaluation of ophthalmic drug efficacy.


Validated Ophthalmic Disease Models

Product ID Product Name Related Diseases Targeting Type
C001395 TG-VEGFA Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR) Humanization(TG)
C001396 B6-hRho Retinitis Pigmentosa (RP) Humanization(KI)
C001384 Pde6b KO Retinitis Pigmentosa (RP), Congenital Stationary Night Blindness (CSNB) KO
C001385 Prph2 KO Retinitis Pigmentosa (RP), Age-related Macular Degeneration (AMD), Macular Dystrophy (MDs) KO
C001386 Tub-KO Retinal Degeneration (RD) KO
C001387 Rpe65 KO Retinal Degeneration (RD), Leber Congenital Amaurosis 2 (LCA2) KO
C001360 B6-Rpe65 R44X Leber Congenital Amaurosis 2 (LCA2) Mu




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