Knockout Mouse Catalog | Cyagen APAC
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  4. Advanced CRISPR/Cas9 Technology

Cas9 can be easily programmed to make DNA double strand breaks (DSBs) in the genome of cells. These breaks are then repaired by the cells’DNA damage repair mechanisms using either the non-homologous end joining (NHEJ) pathway or the homology-directed recombination or repair (HDR) pathway. However, NHEJ-mediated repair of Cas9-generated breaks might generate random/small insertions and deletions at the targeted site during double-stranded break (DSB) repair. While CRISPR-Pro technology offers a solution to the limitations represented by above method. By utilizing Cyagen’s unique fertilized mouse eggs process, repair of DSBs is prone to occur by HDR pathway. The accuracy and efficiency of DSBs repair are greatly improved, which allows for large fragment knockin (up to 15kb) and conditional knockouts.

CRISPR-Pro Advantages

Large fragment: Fragment up to 15kb knockin and 500kb knockout.
Precisely: Express your target gene accurately and precisely.
High efficiency: Improving the efficiency of HDR by using our unique fertilized mouse eggs process.
Guarantee: 100% money-back guarantee.

CRIPSR-Pro Services

Promotion Period: May 18, 2019 - July 1, 2019 The activity is over.

Eligibility: End clients in South Korea, Singapore and New Zealand

Service Turnaround Deliverables List Price Promotion Price (USD)*
Knockout mice 5-9 months 3 F1 $8,000 $8,000
Point mutation mice 6-9 months 3 F1 $17,000 $14,450
Knockin mice (ROSA26) 6-9 months 3 F1 $17,000 $14,450
Conditional knockout mice 6-9 months 3 F1 $20,000 $17,000

* Plus FREE cryopreservation up to three years.

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