BALB/c is a laboratory-bred, albino strain of the house mouse, characterized by its immunodeficiency and extreme susceptibility to carcinogens. BALB/c mice are among the most widely used mouse strains across oncology, immunology, and nuclear medicine research, and are often the first option for animal experimentation models in new drug development projects. In addition, BALB/c mice are well-known for the production of plasmacytomas after injection with mineral oil, leading to their use in the preparation of monoclonal antibodies (mAbs).
Under normal circumstances, the BALB/c-derived embryonic stem (ES) cell proliferation is hard, and the corresponding ES Targeting model is even more difficult to construct. Cyagen has screened several batches of BALB/c-strain ES cells over two and a half years, testing several characteristics – including progenicity, karyotype stability, and totipotency - to finally provide screened BALB/c-derived ES cells suitable for generating targeted genetic models.
The TurboKnockout® service by Cyagen is based on traditional ES cell targeting techniques, which can be used for complex gene knockout projects to provide BALB/c mouse models with accurate genetic modification, 100% germline transmission (GLT), and no off-target effects. Compared with CRISPR/Cas9-based techniques, TurboKnockout® is free of patent disputes and is the technology of choice for drug development projects. For consultation and order, please call 86 20-31601779 or email firstname.lastname@example.org.
|TurboKnockout® Knockout Mice||4 BALB/c TurboKnockout® Mice||Inquire for price|
|TurboKnockout® Conditional Knockout/Knockin Mice||4 BALB/c TurboKnockout® Mice||Inquire for price|
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TurboKnockout® BALB/c Service Advantages
Strict selection standard for BALB/c strain ES cellsCyagen has successively selected several batches of BALB/c strain ES cells, among which each batch has been tested on several factors such as progenicity, karyotype stability, totipotency, reproductive chimerism, and final germline chimerism testing, to finally provide screened BALB/c-derived ES cells suitable for generating targeted genetic models.
Commonly-Used Mouse Strain for Oncology ResearchBALB/c mice are extremely susceptible to carcinogens, leading to their wide use in oncology, immunology, nuclear medicine research, the preparation of monoclonal antibodies (mAbs), and are often the first option for animal experimentation models in new drug development projects.
No Off-Target EffectsTurboKnockout® is based on traditional ES cell targeting techniques, which can be used for complex genetic modification projects to provide BALB/c mouse models with accurate genetic modification, 100% germline transmission (GLT), and no off-target effects.
No Risk of Patent InfringementsCompared with CRISPR/Cas9 techniques, TurboKnockout® is free of patent disputes and is the technique of choice for new drug development projects.
Shorter TurnaroundFounders as fast as 6 months due to innovations that eliminate two generations of breeding: 1) super competent ES cell line generates 100% ESC-derived founders, avoiding the ‘chimera’ phase; and 2) a self-removing Neo selection cassette that circumvents the need to breed to Flp deleter mice.
Cell Metabolism PMID: 32004475 (2020) IF=22.415
Nature 569: 116-120 (2019) IF=41.577
Immunity PMID: 30770248 (2019) IF=19.734
Gut 68: 301-312 (2019) IF=17.016