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Humanized ACE2 Mouse Catalog Models
  • hACE2 Catalog Models

  • Technical Reports for ACE2 Humanized Models

To support researchers investigating the implications of ACE2 in COVID-19 pathology, we have developed many different ACE2 mouse models since the beginning of the pandemic. There are multiple approaches to developing humanized ACE2 (hACE2) models, including ROSA26 conditional knockin (cKI) or endogenous replacement, which yield different proteins.


Using a variety of animal models can serve to elucidate the function of ACE2 in COVID-19 onset.

Through crossbreeding of the initially developed heterozygous hACE2 mice, we are developing mouse models which express both chromosomal copies of the hACE2 sequence. The use of models with a homozygous genotype ensures a consistent genetic expression profile throughout all tissues of an organism. Using homozygous models often enhances the mutant phenotype seen in heterozygous strains.

As part of our continued development of ACE2 mouse models for COVID-19/SARS-CoV-2 research, we are excited to announce that new homozygous hACE2 mouse models are nearly ready for delivery! Additionally, we are able to provide technical reports about the progress on these ACE2 models with rapid delivery to your animal facility!

Fill in the form to get FREE technical consultation!

Eligibility: End clients in APAC region, excluding Japan.
Project Type Backgrounds Deliverables Price (USD/Mouse)
Humanized ACE2
(hACE2) Mice
(Endogenous Replacement)
C57BL/6J heterozygote $300
homozygote $650
C57BL/6N heterozygote $300
BALB/c heterozygote $400
ACE2 Knockin Mice
(H11 Locus)
C57BL/6J heterozygote $300
ACE2 Conditional Knockin Mice
(Rosa26 Locus)
C57BL/6J heterozygote $300
C57BL/6N heterozygote $300
BALB/c heterozygote $400
TurboKnockout® hACE2 Mice
(Endogenous Replacement)
C57BL/6N heterozygote $500
BALB/c heterozygote $600

Genetic Overview

  Background: C57BL/6J Strain
  Gene targeted: Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 [Mus musculus (house mouse)]
  Gene ID: 70008
  Mutation Type: CRISPR/Cas9 mediated gene knockin
  Description: the region from aa.18 to aa.805 of mouse Ace2 will be replaced with the region from aa.18 to aa.805 of human ACE2. The murine signal peptide (aa.1~17) will be remained.
Fill in the form to download PCR Genotyping Report

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