Knockout Mouse Catalog | Cyagen APAC
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  4. ES cell-based conditional knockout mouse

Conditional knockout mouse models play an important role in genetics research. With a conditional KO, researchers can target specific genes at specific times in a certain tissue type. Technologies for obtaining conditional knockouts are also developed and offer researchers more flexibility to obtain desired models. Now, conditional knockouts can be achieved by either traditional ESC-based technology, with the production of chimeric mice or via the CRISPR/Cas9 technology.

Are you Gene Targeting Genius? Express your ideas on above gene targeting technologies by entering our matching game!

Match the following terms before June 30, 2019 and win the 30% OFF promo code on Cyagen's ES cell-based conditional knockout mouse models generated by TurboKnockout®, plus FREE Cre mice and FREE cryopreservation up to three years.

Match the Perfect Group to Win Discounts
5. Potential off-target effects

Enter the matching number in the circle to make the perfect group.

1. Time-consuming 2. Short turnaround time 3. Size limitation 4. More expensive
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Term and conditions

  • ● The campaign is valid for Asia Pacific customers, excluding Japan and China.
  • ● The 30% OFF promo code is valid before June 30, 2019.
  • ● The promo code can be applied to Cyagen's ES cell-based conditional knockout mouse models generated by TurboKnockout®, plus FREE Cre mice and FREE cryopreservation up to three years.
  • ● Questions can be sent to service-apac@cyagen.com or call 86 20-31601779.
TurboKnockout® - The Fastest ESC-based Gene Targeting Technology

TurboKnockout®, Cyagen's proprietary and the fastest ES-cell based gene targeting technology, comparing to traditional gene targeting technology, can eliminate two generations of breeding, allowing generation of conditional knockout mouse models in as fast as 6 months.

Service Turnaround Deliverable
ES cell based conditional knockout mice- TurboKnockout 6-8 months 4 TurboKnockout® mice
Comparison of the Gene Targeting Methods
Item TurboKnockout® Traditional ESC Targeting CRISPR/Cas9
Turnaround 6-8 months 10-14 months 5-9 months
Chimeras production needed No Yes No
Potential off-site target effects No No Yes
Size limitation No No Yes
Germline guarantee Yes Yes Yes
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Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses.
Immunity PMID: 30770248 (2019)
Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy.
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A conserved Shh cis-regulatory module highlights a common developmental origin of unpaired and paired fins.
Nat Genet 50:504-509 (2018)
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