Coronaviruses (CoV) invade human cells mainly through binding with cell membrane receptors; so far, three membrane exopeptidases, DPP4, ACE2, and APN have been identified as entry receptors for human-infecting coronaviruses. Among these, ACE2 is associated with the initial entry and infection of SARS-CoV, while DPP4 is similarly linked with MERS-CoV. At present, APN is only found to relevant to HCoV-229E infectivity, while this coronavirus does not cause severe illness. Although the human coronavirus that combined with APN does not directly lead to lethal disease, with the same high expression level as the receptor of MERS-CoV, it is likely to trigger severe lethal respiratory disease like MERS once infected. Additionally, the spike protein used by coronaviruses to bind to cell surface receptors is susceptible to mutations that alter the target receptors to enter the cell to replicate, which can be seriously life-threatening. Therefore, Cyagen’s expert team of scientists have initiated research and development on animal models for these three main coronavirus receptors, aiming to provide rapid solutions for epidemic prevention research.