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AlphaKnockout Gene Targeting Expert System

AlphaKnockout - Free strategy designing tool
Genetically modified mice generated by gene targeting technologies such as ES targeting or CRISPR/Cas9 have been widely used to study gene functions and human diseases. However, even for sophisticated life scientists, it takes many hours of hard research to come up with a good gene targeting strategy. Cyagen’s gene targeting AI (artificial intelligence) expert system - AlphaKnockout can help you overcome these limitations - its fast, intelligent, reliable, reproducible, and best of all, free.

TurboKnockout® - Fastest ES-cell based gene targeting approach
Cyagen offers a one-stop solution for animal model generation. In addition to free strategy designing with AlphaKnockout, TurboKnockout®, Cyagen's proprietary and the fastest ES-cell based gene targeting platform in the world, also allows you to generate conditional knockout/knockin mouse models in as short as 6 months, 4-6 months shorter than the standard approaches.

Order now, you can enjoy free Cre mice and cryopreservation of strains up to three years.
Service Turnaround Deliverables
Conditional knockout/knockin mice 6-8 months 4 TurboKnockout® mice

How to Order?

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——— Highlights of TurboKnockout® ———
Item TurboKnockout® Traditional ES Cell Targeting
Turnaround 6-8 months 10-14 months
F0 founders 100% ES cell derived Chimeras partially
Self-deleting selection cassette Yes No
Potential off-site target effects No No
Ability to introduce large fragment Yes Yes
Germline guarantee Yes Yes

Faster Turnaround with

● TurboKnockout® ES cell targeting: 6~8 months

● Traditional ES cell targeting: 10~14 months

——— Cyagen’s Advantages ———

Over 12 years of experience
in custom animal model

Working with over 1,000
bioscience institutions
throughout the world

Over 2,300 citations
in SCI journals

Over 26,000 animal models
delivered to date

Our facility can house up to
150,000 SPF animals

An essential receptor for adeno-associated virus infection.
Nature 530:108 (2016) IF= 40.137
The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.
Nat Genet 48:427 (2016) IF= 31.616
Loss of G s α Impairs Liver Regeneration through a Defect in the Crosstalk between cAMP and Growth Factor Signaling.
Cancer Cell 31:697 (2017) IF= 27.407
The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination.
Nat Immunol 18:214 (2017) IF= 21.506