In recent years, rAAV has become the most important delivery vector of gene therapy. The production and preparation of rAAV is a key and difficult point in gene therapy, because the packaging system and purification method of rAAV will influence the infection efficiency and the expression efficiency of the target gene, and ultimately affect the results. The following article will introduce the necessary quality control (QC) inspection items for rAAV after packaging and production.
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Cyagen has a robust bioinformatics database, which can perform analysis across the whole genome for human genes and genetic disorders, animal models, and cell line models. By combining all available data with our expertise in machine learning and deep neural networks (DNNs)
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The newly-developed K18 promoter-driven hACE2-Cre-ERT2 knock-in (hACE2 KI) mouse model with a C57BL/6J background provides an additional platform for continued research.
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This article focuses on the process of developing CAR T-cell therapy and discusses the importance of each preclinical and clinical stage in the research of CAR T-cell therapy.
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The application of recombinant Adeno-Associated Virus (rAAV) drugs in clinical trials of metabolic diseases around the world is mainly concentrated among the following indications
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In Part A, we describe how the Mucopolysaccharidosis IVA (MPS IVA, MPSIVA) rat model is generated. Please see Part B which we explore other promising applications of AAV9-Galns treatments.
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With the development of research on the impact of immunity and inflammation on cancer, the performance of humanized mice attract tremendous attention in cancer clinical research.
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Mucopolysaccharidosis IVA (MPS IVA) - also known as Morquio Syndrome, type A - is inherited in an autosomal recessive manner and caused by mutations in the GALNS gene.
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