The following publications demonstrate the use of custom genetically modified mouse and rat models across a broad range of human disease studies, including immunological disorders, inflammatory disorders, cardiovascular disease, oncology, immunology, and liver disease.
|
Model Type Used |
Research Applications |
Gene Target |
Title |
Journal |
|
Conditional Point Mutation (cPM) Mice |
Cardiology, gene therapy |
Lmna |
Vascular endothelium–targeted Sirt7 gene therapy rejuvenates blood vessels and extends life span in a Hutchinson-Gilford progeria model |
Science Advances DOI: 10.1126/sciadv.aay5556 (2020) |
|
Neurology, aging |
Gm31629 |
Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline. |
Cell Metabolism PMID: 32004475 |
|
|
Conditional KO (cKO) Mice |
Hepatic steatosis, insulin resistance, inflammation |
TMEM16A |
Hepatocyte TMEM16A Deletion Retards NAFLD Progression by Ameliorating Hepatic Glucose Metabolic Disorder |
Advanced Science DOI: 10.1002/advs.201903657 |
|
Immunology, inflammatory disorders |
Drd5 |
Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation. |
Molecular Cell PMID: 32035036 |
|
|
Immunology |
Pde6b rd1 |
MAdCAM-1 mediates retinal neuron degeneration in experimental colitis through recruiting gut-homing CD4+ T cells |
Mucosal Immunology DOI: 10.1038/s41385-020-0282-x |
|
|
Skin inflammation, immunology |
IL36r |
Keratinocyte interleukin-36 receptor expression orchestrates psoriasiform inflammation in mice |
Life Science Alliance PMID: 32086318 |
|
|
Humanized Mice |
Cardiology |
Human CRP |
C-reactive protein derived from perivascular adipose tissue accelerates injury-induced neointimal hyperplasia. |
Journal of Translational Medicine DOI: 10.1186/s12967-020-02226-x |
|
Neurology |
DPYSL2 |
DPYSL2 Is a Novel Regulator for Neural Stem Cell Differentiation in Rats: Revealed by Panax Notoginseng Saponin Administration |
Stem Cell Research & Therapy DOI: 10.1186/s13287-020-01652-4 |
|
|
Oncology |
Sdhb |
A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/- rats. |
Endocrine-Related Cancer PMID: 32252027 |
Genetically engineered animals remain essential for gaining proper understanding of human disease mechanisms and play an important role in a variety of research areas. Since our founding in 2005, Cyagen has been cited in over 3,600 publications – all of which are available as a searchable list.
If you need more information regarding our technologies and how Cyagen can help you further your research, contact us with your gene target(s) and our custom model generation experts will be in touch with you.
We will respond to you in 1-2 business days.