Knockout Mouse Catalog | Cyagen APAC


Though the current situation regarding COVID-19 is still severe, since July, many successes have been achieved on SARS-CoV-2 neutralizing antibody and Phase II clinical trials of SARS-CoV-2 vaccines. With the effort of scientists worldwide, results indicate that research will continue to make progress in the fight against COVID-19.


Herein, we discuss several frequently asked questions regarding both the design of the neutralizing antibody and the progress of vaccines for SARS-CoV-2. What is meant by neutralizing antibody research? What is current progress of SARS-CoV-2 vaccines? How do we verify the safety and efficiency of vaccines with animal models?


1. Neutralizing Antibody Research

  • Coronavirus S protein is a key factor which determines virus virulence, tissue tropism, and host range - which have made it the main target of neutralizing antibody and vaccine design.
  • The most effective neutralizing antibody was BD-368-2, which showed strong therapeutic and preventive effects on hACE2 transgenic mice infected with SARS-COV-2.
  • In hACE2 mouse models, the administration of H014 can simultaneously reduce the SARS-CoV-2 virus titer and mitigate pathological changes in the lungs.


2. Development Progress of SARS-CoV-2 Vaccines

  1. Overview of Immunizations and Vaccines
  2. COVID-19 Vaccine Updates through July 2020
  3. Understanding Antibody-Dependent Enhancement (ADE)
  4. Risks of Antibody-Dependent Enhancement (ADE) of Coronaviruses


3. Applications of Animal Models to Evaluate Vaccine Safety


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Cyagen hACE2 Mice: two main technologies, three strains, multiple targeting strategies - ONLY $300

Cyagen have used the proprietary TurboKnockout® technology and optimized CRISPR-Pro Technology to carry out the development of humanized ACE2 mice base on three background strains: BALB/c, C57BL/6J and C57BL/6N, to meet the needs of different research applications for SARS-CoV-2 drug screening and vaccine development.

Project Type Background Strain
Humanized ACE2 Mice C57BL/6J, C57BL/6N, BALB/c
ACE2 Knockin (KI) Mice (Rosa26 Locus) C57BL/6J
ACE2Gene Knockin (KI) Mice (H11Locus) C57BL/6J
ACE2 Conditional Knockin (cKI) Mice (Rosa26 Locus) C57BL/6J、C57BL/6N、BALB/c
ACE2 Knockout (KO) Mice C57BL/6J、BALB/c

>>Check the detail page for hACE2 Mouse Recommendation


Cyagen One-on-One Webinar: Connected with Cyagen experts

We understand that researchers worldwide are facing unique challenges presented by the COVID-19 pandemic. Our support team is ready to provide complimentary consultations for your research project through our one-on-one webinar.


About Cyagen

In under 15 years since its founding, Cyagen has become a leading provider of custom mouse and rat models – delivering over 50,000 models to researchers worldwide and receiving over 4,000 peer-reviewed citations. We are known to provide the industry’s best price, quality and turnaround time on all our model generation services, and top-quality services we provide are backed by our industry-best 100% money-back guarantee.

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