From January through June of 2020, Cyagen received over 70 citations for our animal models, contributing to many advances across research fields. We have put together the below list of articles from high impact factor (IF) journals to provide insights into a variety of mouse model types, gene targets, research applications, and some of the most recent developments shown in scientific literature.
The following publications demonstrate the use of genetically modified mouse models across a range of human disease research, including atherosclerosis, inflammatory disorders, cardiovascular disease, oncology, metabolism, and virology. All citations listed feature gene targets included among our ready-to-use Cyagen Knockout Catalog Models – as fast as 2 weeks!
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Mouse Model Type Used |
Gene Target |
Research Applications |
Knockout Catalog Model Link |
Title |
Journal Information |
|
Knockin (KI) |
Ldlr |
Atherosclerosis |
In Vivo AAV-CRISPR/Cas9-Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia. |
Circulation DOI: 10.1161/CIRCULATIONAHA.119.042476 |
|
|
Knockout (KO) |
Dapp1 |
Thrombopoiesis |
Melatonin Enhances Thrombopoiesis Through ERK1/2 and Akt Activation Orchestrated by Dual Adaptor for Phosphotyrosine and 3-phosphoinositides |
Journal of Pineal Research DOI: 10.1111/jpi.12637 |
|
|
Drd5 |
Inflammation |
Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation |
Molecular Cell DOI: 10.1016/j.molcel.2020.01.022 |
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|
Conditional Knockout (cKO) |
Steap4 |
Oncology |
Inflammation Mobilizes Copper Metabolism to Promote Colon Tumorigenesis via an IL-17-STEAP4-XIAP Axis |
Nature Communications DOI: 10.1038/s41467-020-14698-y |
|
|
Raly |
Metabolism |
Collaborative Interactions of Heterogenous Ribonucleoproteins Contribute to Transcriptional Regulation of Sterol Metabolism in Mice |
Nature Communications DOI: 10.1038/s41467-020-14711-4 |
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|
Rbck1 |
Virology |
Regulation of the Linear Ubiquitination of STAT1 Controls Antiviral Interferon Signaling |
Nature Communications DOI: 10.1038/s41467-020-14948-z |
Now through August 31st, order any ready-to-use knockout (KO) strains from the Cyagen AI Knockout Mouse Model eBank to receive free cKO mice of the same gene and additional breeding incentives – providing a total savings of $6,000.
Learn more about this offer by visiting the promotional page: Win a KO + Free cKO Model, $6,000 saved up!
Genetically engineered animals remain essential for gaining proper understanding of human disease mechanisms and play an important role in a variety of research areas. Since our founding in 2005, Cyagen has been cited in over 4,000 publications – all of which are available as a searchable list.
For a complimentary consultations and quotes, please call 86 20-31601779 or email service-apac@cyagen.com to get in touch with our model generation experts.
We will respond to you in 1-2 business days.