Knockout Mouse Catalog | Cyagen APAC
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As the pandemic by COVID-19 continues to evolve, Cyagen, as professional providers of animal models with strong social responsibility, remains operational and adapting to developments of the situation. Accurate animal models are necessary for verifying the pathogenesis and immune mechanisms of the illness to accelerate research across vaccine development, new drug development, gene therapy, and more. Therefore, our R&D team of experts has been closely working on developing animal models and targets catered to the global needs for coronaviruses research products and services. Now we are providing knockout (KO), knockin (KI), and humanized mouse models at multiple hot targets - ACE2, DPP4, TMPRSS2, CD147, and so on at special offer, to supporting COVID-19 research efforts. For consultation and order, please call 86 20-31601779 or email service-apac@cyagen.com.

● Promotion Period: April 23th - June 30th 2020

● Eligibility: End clients in Australia, New Zealand. Other Regions, please contact us.

● For humanized models, knockout models, Rosa26 knockin mouse models of ACE2 and DPP4 on C57BL/6 mouse strains,
the exclusive sales prices are as below:

ACE2 / DPP4 Service Name Deliverable Promotion Price (USD/Strain)
Knockout Mice ≧3 F1 Heterozygotes 3,599
Humanized Mice ≧3 F1 Heterozygotes 8,400
Knockin Mice (Rosa26) ≧3 F1 Heterozygotes 9,600

● Note: Cyagen can also offer mouse models in BALB/c background, please contact us for further information.

Targets of Significance for Coronavirus Research
Targets The Target’s Role in Viral Infections

ACE2

(Angiotensin-converting Enzyme 2)

KO Mice

cKO Mice

Humanized Mice (Online Consultation)

● Angiotensin-converting Enzyme 2 (ACE2) is the functional receptor of the SARS virus；

● Research has shown that when SARS coronavirus invade cells via cell surfaces expressing ACE2, its infection efficacy increased by 10 times;

● SARS-CoV-2 is rampant among human beings, with the resulting COVID-19 mainly causing damage to the lungs, which is closely related to the distribution of ACE2 in the pulmonary tissues；

● ACE2 can be regarded as the primary gene of interest for SARS-induced respiratory illness alongside its use in researching lung diseases such as pulmonary fibrosis, pulmonary inflammation, and even lung cancer.

DPP4

(Dipeptidyl peptidase-4)

KO Mice

cKO Mice

Humanized Mice (Online Consultation)

● Dipeptidyl peptidase-4 (DPP4) is the exo-peptidase that was found to be a coronavirus receptor;

● The direct and specific binding of MERS-CoV S1 with human DPP4 leads to the occurrence of Middle East respiratory syndrome (MERS);

● The structural characteristics of DDP4 binding with MERS-CoV RBD is helpful for us to understand the interaction between virus and receptor and guide the treatment of MERS-CoV infection towards the development of a vaccine.

APN

(Aminopeptidase N)

KO Mice

cKO Mice

Humanized Mice (Online Consultation)

● APN is associated with the infection of HCoV-229E coronavirus;

● It’s significant for the study of the host receptor mechanism for infection by the SARS-CoV-2.

TMPRSS2

(Transmembrane Serine Protease 2)

KO Mice

cKO Mice

Humanized Mice (Online Consultation)

● The transmembrane protease TMPRSS2 participates in the fusion process of ACE2 and SARS-CoV-2 membrane;

● TMPRSS2 is a synaptic protein that activates highly pathogenic hCoVs.

ADAM17

(ADAM Metallopeptidase Domain 17)

KO/KI/Humanized Mice
(Online Consultation)

● The binding of SARS-CoV S protein (SARS-S) and ACE2 triggers the cleavage of ACE2 by ADAM17, which helps ACE2 to fall into vascular endothelial cells (ECs) and promotes the entry of SARS-CoV into cells;

● ADAM17 was found to compete with the TMPRSS2 in the interaction with ACE2.

LY6E

(Lymphocyte Antigen 6 Complex, Locus E)

cKO Mice

Humanized Mice (Online Consultation)

● LY6E is involved in the modulation of viral infection;

● LY6E can regulate cell signaling, including the host immune response, which is essential for defending against viral infections;

● LY6E inhibits CoV entry into cells by interfering with S protein-mediated membrane fusion.

SIGN/CD209L

(Cluster of Differentiation 209)

KO/KI/Humanized Mice
(Online Consultation)

● Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection;

● SARS coronavirus entry into host cells through the binding of hypermannan on the S protein and CD209L (L-SIGN) on the plasma membrane.

CD147

(Cluster of Differentiation 147)

KO/KI/Humanized Mice
(Online Consultation)

● SARS-CoV-2 invaded host cells via a novel route of CD147-spike (S) protein;

● CD147 may serve as a receptor on the host for the SARS-CoV-2 S protein, which participates in the interaction between the viruses and cells, thereby mediating the viral invasion;

● CD147 can be used as a critical target for development of specific antiviral drugs.

DHODH

(Cluster of Differentiation 147)

cKO Mice

KO/KI/Humanized Mice
(Online Consultation)

● A novel and potent inhibitor of DHODH exhibits broad-spectrum antiviral characteristics against RNA viruses;

● RNA virus may be more sensitive to DHODH activity, DHODH plays a critical role in RNA virus replication process.

In addition to above targets, if you would like to order any other models related to the research of SARS-CoV-2, corroborating materials on its feasibility should be provided. Once approved by our experts, you may be offered a special offer for your project.

How to Order
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Cyagen Coronavirus Research News & Updates

●Cyagen Thematic Compilation of Coronavirus: everything you need to know about the Novel Coronavirus (COVID-19)


●Beyond Mediating Host Cell Entry of SARS-CoV-2: What Roles Does ACE2 Play?


●Beyond ACE2: Additional Targets of Significance for Coronavirus Research


●Cytokine Storm: The New Perspective for COVID-19 Research


●How does coronavirus enter the cell through a host receptor?


●How does coronavirus invade cells? How can we respond to it ?


●Researching the New Coronavirus, SARS-CoV-2: Applications for Animal Models


●Cyagen White Paper: Infectivity and Immune Mechanisms of Coronaviruses & SARS-CoV-2


●Interview: Impact of COVID-19 Respiratory Illness on the Life Science Research Industry

Cyagen Advantages

Well-Established Platform

Lead by internationally renowned Cyagen scientists, 15-years’ experience, successfully delivered over 50,000 custom animal models to researchers across the globe.

Professional Technical Support

Cyagen's project management team will reasonably control the process quality in accordance with your preference or requirements. We provide you with an experimental scheme as well as up-to-date project reports and post-delivery consultation services, helping to minimize both your time and energy spent managing the project.

AAALAC-Accredited and OLAW Assured

The Cyagen Transgenic Animal Center (CTAC) is AAALAC-accredited and OLAW assured - demonstrating Cyagen's adherence to strict guidelines for the care and use of animals.

World-Class Facilities

Specific-pathogen-free (SPF) animal health status and strict adherence to protocol provides more reliable experimental statistics. To ensure the efficient operation of the animal room, our center is equipped with medical ground sterilizers, automatic cage cleaning machines, ozone and ultraviolet (UV) disinfection facility, automatic waste collection, and odor removal systems.
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