Tumor cells are widely used in establishing tumor models due to its ease of access and low cost. In addition, there are many publications and data on genomics, cell function, and pharmacodynamic responses available for reference.
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Immunodeficient mice refer to the mice with defects in one or more immune components (such as T, B, NK cells) in the immune system. This type of mouse is widely used in the research of oncology (tumor growth, metastasis, anti-tumor drug screening), immunology (mechanisms of immune cell development and proliferation, pathology of immune diseases), infectious diseases (pathogenic mechanisms of viral/bacterial infectious diseases), and stem cell biology (human stem cell transplantation), and more.
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Animal models play an important role in the preclinical evaluation of anti-tumor drugs. The establishment of tumor animal models provide a powerful tool for studying the mechanism of tumorigenesis and metastasis, even validating the efficacy of anti-tumor drugs. Rodent models have many advantages in tumor research, such as fast breeding, low cost, and versatile genetic modification. These traits make them an indispensable tool for preclinical therapeutics screening.
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Neurodevelopmental disorders are impairments of the brain and central nervous system that affect a patient’s behavior and cognition. In this article we review the MECP2 gene, a pathogenic gene of neurodevelopmental disorders, hoping to help researchers gaining proper understanding of the gene, its encoded MeCP2 protein, and related neurodevelopmental disorders.
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Cyagen has expanded our services to include additional options for phenotype analysis. Our extended downstream animal model supporting services provide optimal solutions for researchers worldwide to create, manage, and monitor models with ease.
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Transgenic rats are animal models which have foreign DNA incorporated into the rat genome and are used to research a wide range of gene functions and human diseases. In this article, we review the basic information on transgenic rat models, research application examples, and how they can be developed.
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After deciding upon a CRISPR-mediated gene knockout strategy and obtaining the gRNA, the next step would be choosing the suitable strategy for cell transfection to introduce gRNA and Cas9 protein into cells. The efficiency of this transfection step directly affects the overall success rate of CRISPR/Cas-mediated gene editing and subsequent model generation.
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A humanized mouse model is a broad term referring to a mouse engrafted with functional human genes, cells, or tissues. This type of model is usually used as an powerful in vivo model for preclinical study of human diseases. Humanized mouse models have become an important animal model for identifying how human genes impact development and disease.
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Gene knock-in (KI), a.k.a. knockin, mice are generated by introducing specific mutations or exogenous genes into specific sites of the target gene through homologous recombination, so that the expression of the gene knockin may be tracked through the expression of a reporter.
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