In general, metabolic disorders lead to abnormal accumulation or lack of metabolic substances in the body - such metabolic diseases have serious impacts on human health. Metabolic syndrome is characterized by a combination of obesity accompanied with other metabolic abnormalities, such as hypertriglyceridemia, decreased HDL levels, elevated blood pressure, and elevated fasting blood glucose levels. Obesity is increasing worldwide, and its association with these metabolic symptoms increases the risk of diabetes, cardiovascular disease, and stroke.
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The traditional approaches used in gene function studies, especially in cell lines, include gene interference, gene overexpression, and gene knockout. Herein, we will focus on discussing the most popular approach, gene knockout – a mutation that inactivates a gene function.
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PD ranks second among neurodegenerative diseases. The most well-known symptom of PD is involuntary tremors, characterized by uncontrolled shaking, most notably in the hands. Another important symptom is the weakening of balance ability, but it should be noted that the weakening of balance has nothing to do with cerebellar injury.
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In higher eukaryotes, most genes contain introns. After transcription is complete, the removal of introns from mRNA should be done by splicing to generate mature and translationally active mRNA. This process is carried out and stimulated by the spliceosome. The main spliceosome contains five types of snRNA (small nuclear RNA), i.e., U1, U2, U4, U5 and U6, as well as the protein factors that interact with them [1]. Among them, U6 snRNA is at the core and most conservative position. It is located at the catalytic center of the spliceosome, which is essential for the catalytic activity of the spliceosome.
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With continuous advancement, our searchable Knockout Catalog Model Repository contains over 16k custom knockout (KO) and cKO/floxed strains available to researchers with delivery in as fast as 3 months. We aim to increase mouse model accessibility for researchers worldwide providing high-quality rodent models in the most economic and efficient way.
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Alzheimer’s disease (AD) maintains the highest prevalence and morbidity among neurodegenerative diseases. Memory loss is the key symptom of AD, the aggravation of which will lead to other symptoms associated with the disease development, and eventually lead to death of the patients. AD brings suffering to the patients and their families - a heavy burden on society.
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We have selected several high-impact factor (IF) publications which use conditional knockout (cKO), a.k.a. floxed, mouse models developed by Cyagen. The following publications demonstrate the use of conditional knockout mouse models across a range of human disease research fields, including immunology, cardiology, metabolomics, oncology and more.
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Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder, which affects 20 to 30 million individuals worldwide. Currently, no effective therapies to treat or cure this disease have been developed. As a leading provider of custom mouse and rat models, Cyagen aims to support the advancement of Alzheimer's disease (AD) research with our expertise.
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Knockout mice have been essential for gaining proper understanding of gene function, studying human disease mechanisms, and accelerating drug development - playing an important role in biomedical advancements across a variety of research areas. With the development of gene editing technology, knockout (KO) mice become increasingly accessible for researchers worldwide. In this article, we review the basic information on knockout mice research, application examples, and the development process for custom KO mouse models.
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As a leading provider of custom mouse and rat models, Cyagen aims to support the advancement of rare disease and related gene therapy research with our expertise. We are committed to enabling development of therapeutics for rare diseases by developing accessible animal models to study disease mechanisms, target validation, drug screening and more.
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