Cyagen Conditional Knockout Mouse Model Publication Alert
We have selected several high-impact factor (IF) publications which use conditional knockout (cKO), a.k.a. floxed, mouse models developed by Cyagen. The following publications demonstrate the use of conditional knockout mouse models across a range of human disease research fields, including immunology, cardiology, metabolomics, oncology and more.
Featured Conditional Knockout Mouse Model Publications
Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling.
Nature Immunology PMID: 31636462
Cell Biology, Cardiovascular
Inhibition of S-Adenosyl homocysteine Hydrolase Induces Endothelial Dysfunction via Epigenetic Regulation of p66shc-Mediated Oxidative Stress Pathway
LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice
Molecular Cell DOI: 10.1016/j.molcel.2020.01.002
Hepatic CREBZF Couples Insulin to Lipogenesis by Inhibiting Insig activity and Contributes to Hepatic Steatosis in Diet-Induced Insulin-Resistant Mice
Hepatology DOI: 10.1002/hep.29926
Genetically engineered animals remain essential for gaining proper understanding of human disease mechanisms and play an important role in a variety of research areas. Since our founding in 2005, Cyagen has been cited in over 4,800 publications – all of which are available as a searchable list:
Cyagen's all-in-one innovative CRO service network platform can provide genetically engineered mouse models, ready-to-use models, and model supporting services for your demands on experimental animal models:
TurboKnockout® Gene Targeting Services
TurboKnockout® services can deliver conditional knockout (cKO/floxed) in as fast as 6 months. For TurboKnockout®-mediated conditional knockout (cKO/floxed) mice, it may be possible to breed founders directly to your tissue-specific Cre mice.
Advantages of TurboKnockout®
● Freedom to Operate: Technology of choice for drug development projects ● Success Rate: 100% guaranteed germline transmission (GLT) ● Turnaround Time: Founders as fast as 6-8 months ● Large Fragment Knockin: Insert fragments up to 300 kb ● Flexible Floxing: No size limitations for your floxed region ● 100% Money-Back Guarantee
Cyagen's CRISPR-based gene targeting services can generate conditional knockout models - in as fast as 3 months.
Advantages of CRISPR Mouse Model Generation
● Large fragment: Fragments up to 15kb knockin and 500kb knockout ● Precise: Express your target gene accurately and precisely ● High efficiency: Improved HDR efficiency by using our unique fertilized mouse eggs process ● Guarantee: 100% money-back guarantee.
Cyagen Knockout Catalog Models repository provides a searchable listing of over 16k KO and cKO/floxed mouse strains with 100% pure B6 background, delivering affordable and ready-to-use live KO/cKO models to both research institutions and pharmaceutical corporations in as few as 3 months.
Cyagen has established a range of supporting services, such as animal breeding, embryo/sperm cryopreservation, phenotype analysis services. Outsourcing these services to Cyagen is a more cost-effective way of conducting your research. All these services are performed by experienced specialists following standardized procedures, so we can guarantee delivery of high quality services and data acquisition with unbeatable price and turnaround.
● Phenotype Analysis Services ● Breeding Service ● Cryopreservation Service ● BAC Modification (Recombineering)