As researchers seek the most accurate animal models for in vivo experiments, the availability of gene-editing technologies for developing both mouse and rat models has created more options than ever before. Murine genomes share great similarity with the human genome, which has made them fantastic models for a wide range human disease research.
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With over 300 million people worldwide living with a rare disease, Rare Disease Day aims to raise awareness of what it means to be rare. On the last day of February each year, the Rare Disease community comes together to work toward more equitable access to diagnosis, treatment, care, and social opportunity for people with a rare disease.
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In most experiments, scientists will try to minimize the number of independent variables so as not to confuse the results of an experiment. Due to the varying level of gene expression achieved by traditional pronuclear injection (PNI), using the offspring from a transgenic mouse created via PNI may not be the best option.
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The APOE gene - which encodes Apolipoprotein E – has been extensively studied due to its biological relevance to a range of neurological and cardiovascular diseases, including Alzheimer’s Disease (AD). In addition to the roles APOE plays in developmental diseases such as AD, additional studies have shown APOE to be implicated in the host response to a range of infectious pathogens, including herpes simplex virus type I (HSV1) and hepatitis C virus (HCV).
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As we review our accomplishments in 2020, we are delighted to share how our research partners have used our products and services to contribute to advances across numerous fields of study.
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From the creation of the first knockout (KO) mouse, scientists have come extremely far. CRISPR technologies have quickly become a leading method used by genetic knockout scientists today, in part due to the method’s short turnaround.
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Since the beginnings of gene editing research, the ability to accurately modify large genomic regions has remained a primary driver of innovation in the field. Although gene editing technologies have been continuously refined, the size of the modifiable region is still constrained depending on the methods used.
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Herein, we have selected several high-impact factor (IF) publications from May through October 2020, which use custom genetically modified mouse models developed by Cyagen. These citations cover a broad range of research fields, including immunology, inflammation, cardiology, oncology, metabolomics, and epigenetics.
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Happy Halloween from Cyagen! To celebrate and educate, our team has put together brief synopses of several genes related to fear: STMN1, P4H-TM, ANXA1, FPR1, DAGLA, and TAAR1. Read on to learn about each gene’s functions, research progress, and opportunities for discovery.
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Animal modeling has a played a prominent role in traditional scientific research for hundreds of years. More recently, inbred strains have been developed to support genetically modified models – sometimes called the “living reagents” or “living instruments” of biomedical and health research.
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