Herein, we have selected several high-impact factor (IF) publications from May through October 2020, which use custom genetically modified mouse models developed by Cyagen. These citations cover a broad range of research fields, including immunology, inflammation, cardiology, oncology, metabolomics, and epigenetics.
|
Mouse Model Type Used |
Research Applications |
Gene Target(s) |
Title |
Journal |
|
TurboKnockout® Humanized Point Mutation (PM) |
Leukemia, oncology, tumors |
Gata2 (G320D) |
C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia Through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor |
Cancer Cell PMID: 32330454 |
|
Knockin (KI) (CRISPR) |
Epigenetics, metabolomics, oncology |
Ezh2K735R |
SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways |
Cancer Cell PMID: 32619406 |
|
Stem cells, coronary disease, internal ribosomal entry site (IRES) |
Myh11-DreERT2 Lgals3-IRES-Cre |
The Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis |
Circulation PMID: 32674599 |
|
|
Cardiology |
CHAPIR |
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N 6-methyladenosine methylation of Parp10 mRNA |
Nature Cell Biology PMID: 33020597 |
|
|
Immunology, Inflammation
|
NMBR |
Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition |
Nature Immunology PMID: 32807943 |
Genetically engineered animals remain essential for gaining proper understanding of human disease mechanisms and play an important role in a variety of research areas. Since our founding in 2005, Cyagen has been cited in over 4,300 publications – all of which are available as a searchable list: Browse All Citations
From vector and strategy design to animal model creation, cryopreservation, and breeding, Cyagen offers complete outsourcing for all animal model needs. Cyagen’s price matching policy guarantees you get the best deal. See how we can help further your research: contact us with your gene target(s) and our custom model generation experts will be in touch with you.
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