The following knockout mice and humanized mouse models, generated by replacing murine genes with their human counterparts, can be used for cardiovascular disease (CVD) or Alzheimer's disease (AD) research:
| Mouse Model | Role in Cardiovascular Disease (CVD) |
| APOE Knockout Mice | Lacking APOE protein, these mouse models exhibit five times the normal serum plasma cholesterol and spontaneous atherosclerotic lesions. |
| APPSWE Humanized Mice | Expresses human APPSWE; exhibits an increased risk of atherosclerosis compared to wild type mice; develops significant amyloid plaques and displays memory deficits. Useful for the study of Alzheimer's disease (AD). |