Knockout Mouse Catalog | Cyagen APAC

Cardiovascular Disease Models



The following knockout mice and humanized mouse models, generated by replacing murine genes with their human counterparts, can be used for cardiovascular disease (CVD) or Alzheimer's disease (AD) research: 


Mouse Model Role in Cardiovascular Disease (CVD)
APOE Knockout Mice Lacking APOE protein, these mouse models exhibit five times the normal serum plasma cholesterol and spontaneous atherosclerotic lesions.
APPSWE Humanized Mice Expresses human APPSWE; exhibits an increased risk of atherosclerosis compared to wild type mice; develops significant amyloid plaques and displays memory deficits. Useful for the study of Alzheimer's disease (AD).
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