Conditional knockout (cKO) mice can be used to study specific gene functions and related human diseases. Compared with traditional knockout (KO) mice, conditional knockout mice are obtained with a gene that deleted only in specific tissues or on an inducible basis. Compared with constitutively expressed gene mutations, conditional models provide greater temporal and regional control of gene expression – often serving as a more accurate model for studying human diseases.
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Transgenic mice are important tools for scientists to study genetic disorders and human diseases. In this article, we review the basic information on transgenic mice research, application examples, and the development process for transgenic mouse models – serving as a guide for scientists looking to gain proper understanding of transgenic mouse models.
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Population aging is one of the most important social health issues in the world today and will only increase in the future. With rising life expectancy and continually low fertility rate in developed economies, it is estimated that the number of people aged 65 years or over will be 2.1 billion by 2050 - reaching as many as 3.1 billion by 2100.
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As a leading provider of custom mouse and rat models, Cyagen aims to support the advancement of rare disease and related gene therapy research with our expertise. We are committed to enabling development of therapeutics for rare diseases by developing accessible animal models to study disease mechanisms, target validation, drug screening and more.
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Familial hypercholesterolemia (FH) is characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) and premature cardiovascular disease (CVD). FH is an autosomal dominant genetic disease (with a gene dosage effect) that is caused by mutations in genes encoding low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB) or subtilisin converting enzyme 9 (PCSK9). Around 90% of FH is caused by LDLR mutations.
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The APOE gene - which encodes Apolipoprotein E – has been extensively studied due to its biological relevance to a range of neurological and cardiovascular diseases, including Alzheimer’s Disease (AD). In addition to the roles APOE plays in developmental diseases such as AD, additional studies have shown APOE to be implicated in the host response to a range of infectious pathogens, including herpes simplex virus type I (HSV1) and hepatitis C virus (HCV).
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Transgenic mice are important tools for scientists researching heritable traits and diseases in human populations. In traditional transgenics, the human gene (packaged in a transgenic construct) can be added to the mouse genome with a simple pronuclear injection into the male pronucleus.
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As we review our accomplishments in 2020, we are delighted to share how our research partners have used our products and services to contribute to advances across numerous fields of study.
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A recent study has suggested that that NF-kB activation is boosted by colocalization of engaged immune receptors (i.e., CD40) with RAB7 small GTPase on mature endosomes in mouse B cells. This research was enabled by using a conditional (floxed) gene knockin mouse model - Cd19+/creRosa26+/fl-STOP-fl-Rab7 (Rab7 B-Tg) – which is designed to express untagged RAB7 in CD19+ B cells.
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Establishing appropriate animal models of disease is of vital importance in basic medical research – for which, rats and mice have become the animals of choice. Mice are considered the most important model animal for analyzing human gene functions due to its small size, low operational costs, relatively stable embryonic cells, and pliability for various genetic manipulations and gene editing.
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