The principle of CAR-T cell immunotherapy is to use genetic engineering methods to express chimeric antigen receptor (CAR) molecules on the surface of T cells.
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As of this year, there have been hundreds of recombinant adeno-associated virus (rAAV) gene therapy products approved to be marketed and entered into clinical trials worldwide. Why does AAV vector have such potential?
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When establishing a CRISPR/Cas9-based knockout (KO) cell line model, it is important to validate the genetic modifications which have occurred.
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If you want to effectively achieve gene up-regulation or knockdown, constructing an overexpression stable cell line through lentiviral transfection will be your best choice.
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Gene therapy aims to treat or cure genetic diseases through the introduction of foreign, normally-functioning genes into target cells to correct or compensate for defective or abnormal genes.
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Cell line-derived tumor xenograft (CDX) models play an important role in basic research of tumorigenesis and metastasis, as well as drug development and treatment. Therefore, establishing a precise animal model is vital for accurate in vivo tumor studies and in advancing oncology research.
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Alzheimer’s disease (AD) maintains the highest prevalence and morbidity among neurodegenerative diseases. As the FDA approved the first-of-its-kind treatment for Alzheimer’s disease in June 2021, Alzheimer’s drug development has come into the spotlight.
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