With the rapid development of human antibody production, using gene editing technology to construct humanized mice with human antibodies has become an important subject in antibody drug discovery. However, due to the large genomic region of human antibody Ig genes, it makes the construction of humanized mice that express the human antibody tremendously challenging. Accordingly, it remains difficult to achieve large-fragment human antibody gene insert in animal models, especially for gene that is greater than 1 Mb.
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The continuous development and improvement of gene editing technology has driven the successful establishment of such a platform for mouse models expressing human antibody genes. This has not only led to revolutionary innovations in the research and development of therapeutic antibody drugs, but has also served to promote their wide clinical applications.
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To reduce the immunogenicity of mouse antibodies, chimeric antibody and human antibody strategies have been developed and quickly become important technologies in the antibody drug research. The establishment of phage display technology allows researchers to successfully screen and obtain the first fully human antibody with high affinity.
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The therapeutic antibody has become a leading treatment option for cancers and other related diseases. In the past 25 years, antibody therapy has become an important treatment method for various diseases, such as cancer. Notably, from 2018 to 2019, there were about 18 new therapeutic antibody drugs approved for clinical use.
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Tumor cells are widely used in establishing tumor models due to its ease of access and low cost. In addition, there are many publications and data on genomics, cell function, and pharmacodynamic responses available for reference.
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Immunodeficient mice refer to the mice with defects in one or more immune components (such as T, B, NK cells) in the immune system. This type of mouse is widely used in the research of oncology (tumor growth, metastasis, anti-tumor drug screening), immunology (mechanisms of immune cell development and proliferation, pathology of immune diseases), infectious diseases (pathogenic mechanisms of viral/bacterial infectious diseases), and stem cell biology (human stem cell transplantation), and more.
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Animal models play an important role in the preclinical evaluation of anti-tumor drugs. The establishment of tumor animal models provide a powerful tool for studying the mechanism of tumorigenesis and metastasis, even validating the efficacy of anti-tumor drugs. Rodent models have many advantages in tumor research, such as fast breeding, low cost, and versatile genetic modification. These traits make them an indispensable tool for preclinical therapeutics screening.
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Neurodevelopmental disorders are impairments of the brain and central nervous system that affect a patient’s behavior and cognition. In this article we review the MECP2 gene, a pathogenic gene of neurodevelopmental disorders, hoping to help researchers gaining proper understanding of the gene, its encoded MeCP2 protein, and related neurodevelopmental disorders.
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Cyagen has expanded our services to include additional options for phenotype analysis. Our extended downstream animal model supporting services provide optimal solutions for researchers worldwide to create, manage, and monitor models with ease.
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