Alzheimer’s disease (AD) maintains the highest prevalence and morbidity among neurodegenerative diseases. Memory loss is the key symptom of AD, the aggravation of which will lead to other symptoms associated with the disease development, and eventually lead to death of the patients. AD brings suffering to the patients and their families - a heavy burden on society.
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We have selected several high-impact factor (IF) publications which use conditional knockout (cKO), a.k.a. floxed, mouse models developed by Cyagen. The following publications demonstrate the use of conditional knockout mouse models across a range of human disease research fields, including immunology, cardiology, metabolomics, oncology and more.
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Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder, which affects 20 to 30 million individuals worldwide. Currently, no effective therapies to treat or cure this disease have been developed. As a leading provider of custom mouse and rat models, Cyagen aims to support the advancement of Alzheimer's disease (AD) research with our expertise.
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Conditional knockout (cKO) mice can be used to study specific gene functions and related human diseases. Compared with traditional knockout (KO) mice, conditional knockout mice are obtained with a gene that deleted only in specific tissues or on an inducible basis. Compared with constitutively expressed gene mutations, conditional models provide greater temporal and regional control of gene expression – often serving as a more accurate model for studying human diseases.
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Parkinson's Disease (PD) is a neurodegenerative disease that cannot be cured. In this article, we review the background information, research insights and applications on LRRK2, a pathogenic gene of PD, providing useful information for further scientific innovation.
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Parkinson's disease (PD) is a neurodegenerative disorder that affects behavior and motor skills. In this article, we review the background information, research insights, and applications related to PRKN, a pathogenic gene of PD.
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Transgenic mice are important tools for scientists to study genetic disorders and human diseases. In this article, we review the basic information on transgenic mice research, application examples, and the development process for transgenic mouse models – serving as a guide for scientists looking to gain proper understanding of transgenic mouse models.
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Neurodegenerative diseases have a multitude of factors contributing to their pathogenesis. In the first of our Weekly Gene features covering pathogenic genes of neurodegenerative diseases, we review the functionality of TARDBP. This review, as well as the upcoming Weekly Gene articles, aim to help researchers explore potential therapeutics for neurogenerative diseases.
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It is well known that genes play a major role in the pathogenesis of neurodegenerative diseases. There have been major efforts in biomedical research to learn about disease-related genes, which has led to highly targeted therapeutics for several diseases that were previously untreatable. In this article, we review the functionality of SNCA and explore its role in targeted gene therapy for neurodegenerative diseases, presenting brief technical insights on the state of SNCA gene research.
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Population aging is one of the most important social health issues in the world today and will only increase in the future. With rising life expectancy and continually low fertility rate in developed economies, it is estimated that the number of people aged 65 years or over will be 2.1 billion by 2050 - reaching as many as 3.1 billion by 2100.
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