The APOE gene - which encodes Apolipoprotein E – has been extensively studied due to its biological relevance to a range of neurological and cardiovascular diseases, including Alzheimer’s Disease (AD). In addition to the roles APOE plays in developmental diseases such as AD, additional studies have shown APOE to be implicated in the host response to a range of infectious pathogens, including herpes simplex virus type I (HSV1) and hepatitis C virus (HCV).
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Transgenic mice are important tools for scientists researching heritable traits and diseases in human populations. In traditional transgenics, the human gene (packaged in a transgenic construct) can be added to the mouse genome with a simple pronuclear injection into the male pronucleus.
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As we review our accomplishments in 2020, we are delighted to share how our research partners have used our products and services to contribute to advances across numerous fields of study.
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From the creation of the first knockout (KO) mouse, scientists have come extremely far. CRISPR technologies have quickly become a leading method used by genetic knockout scientists today, in part due to the method’s short turnaround.
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A recent study has suggested that that NF-kB activation is boosted by colocalization of engaged immune receptors (i.e., CD40) with RAB7 small GTPase on mature endosomes in mouse B cells. This research was enabled by using a conditional (floxed) gene knockin mouse model - Cd19+/creRosa26+/fl-STOP-fl-Rab7 (Rab7 B-Tg) – which is designed to express untagged RAB7 in CD19+ B cells.
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Several mutations in APOE (Apolipoprotein E) have been identified to not only increase the risk of developing AD, but other neurological and cardiovascular diseases. As scientists continue to evaluate potential therapies for AD, we hope to provide insights into various genes, related pathways, and research accomplishments in every Gene of the Week article. Herein, we summarize the current research progress on APOE functionality and review its role in Alzheimer's disease (AD).
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Specific mutations in TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) have been confirmed to increase the risk of developing late-onset AD. Here, we review the current data detailing the function of TREM2 and its role in Alzheimer's disease (AD).
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Since the beginnings of gene editing research, the ability to accurately modify large genomic regions has remained a primary driver of innovation in the field. Although gene editing technologies have been continuously refined, the size of the modifiable region is still constrained depending on the methods used.
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Herein, we have selected several high-impact factor (IF) publications from May through October 2020, which use custom genetically modified mouse models developed by Cyagen. These citations cover a broad range of research fields, including immunology, inflammation, cardiology, oncology, metabolomics, and epigenetics.
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The rapidly growing branch of biomedical research known as translational medicine is aimed at the practical problems from clinical patients. A combination of molecular, cellular, and animal models in related basic and preclinical studies can help address the problems of translational research. Therefore, a major strategy of translational medical research is to combine the basic laboratory studies with the preclinical animal experimental research and rapidly move into clinical application.
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![[Gene of the Week] Alzheimer's Disease and Genes - APOE (Apolipoprotein E)](https://apac.cdn.cyagen.com/media/uploads/157x118-APOE.jpg)
![[Gene of the Week] Alzheimer's Disease and Genes - TREM2](https://apac.cdn.cyagen.com/media/uploads/157x118-TREM2.jpg)
