Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder, which is affecting 20 to 30 million individuals worldwide now. Currently, no effective therapies to treat or cure this disease were developed. In this review, we discuss the current research and understanding of the PSEN1 gene and its mutation in causing familial Alzheimer's disease (FAD).
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Happy Halloween from Cyagen! To celebrate and educate, our team has put together brief synopses of several genes related to fear: STMN1, P4H-TM, ANXA1, FPR1, DAGLA, and TAAR1. Read on to learn about each gene’s functions, research progress, and opportunities for discovery.
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Animal modeling has a played a prominent role in traditional scientific research for hundreds of years. More recently, inbred strains have been developed to support genetically modified models – sometimes called the “living reagents” or “living instruments” of biomedical and health research.
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It is well known that genes play a major role in many human diseases - for this reason they are an important research topic in the field of life science and medicine. How can the public quickly grasp the recent research on disease-related genes, when the only resources out about them are long complex academic journals? To save the time and energy of researchers, Cyagen has launched its new project -‘Gene of the Week’...
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Application of the Cre-Lox system is often used to achieve custom spatiotemporal operations on specific genes, which is useful for the study of gene function and animal models of human disease. Herein, we explore the Cre-Lox system and its profound impact on animal model construction capabilities.
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With the enhanced control of rat embryos and the use of CRISPR/Cas9 technology, the scope of applications for rats as experimental model animals in basic research, drug screenings, and preclinical drug evaluations has expanded.
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Establishing appropriate animal models of disease is of vital importance in basic medical research – for which, rats and mice have become the animals of choice. Mice are considered the most important model animal for analyzing human gene functions due to its small size, low operational costs, relatively stable embryonic cells, and pliability for various genetic manipulations and gene editing.
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Though the current situation regarding COVID-19 is still severe, since July, many successes have been achieved on SARS-CoV-2 neutralizing antibody and Phase II clinical trials of SARS-CoV-2 vaccines. With the effort of scientists worldwide, results indicate that research will continue to make progress in the fight against COVID-19.
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The heterogenous nuclear ribonucleoprotein (hnRNP) family are multifunctional complexes of RNA and protein present in the cell nucleus that serve critical roles in gene regulation. Multiple lines of evidence have linked hnRNP abnormalities as key pathobiological drivers of cancer and neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
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The pneumonia-like COVID-19 caused by the novel coronavirus (SARS-CoV-2) remains a huge medical challenge worldwide. To provide a wholistic guide for developing clinical treatments, vaccines, and antiviral drugs, it is of great significance to study the interaction mechanisms between severe acute respiratory syndrome (SARS) coronaviruses and host molecules, while also exploring the pathogenic process of coronaviruses.
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![[Gene of the Week] Alzheimer's Disease and Genes - PSEN1 (Presenilin 1)](https://apac.cdn.cyagen.com/media/uploads/PSEN1_基因-TB小图.jpg)
![[Gene of the Week] Alzheimer's Disease and Genes - APP (Amyloid Precursor Protein)](https://apac.cdn.cyagen.com/media/uploads/Gene_of_the_Week_Alzheimers_Disease_and_Genes_-_APP_Amyloid_Precursor_Protein.jpg)
