Parkinson's disease (PD) is a neurodegenerative disorder that predominantly affects dopamine-producing (“dopaminergic”) neurons in a specific area of the brain, called the substantia nigra.
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The establishment of these mouse models is helpful for research on the function of the hnRNP C1 and C2 proteins and the regulatory expression of the splicing factor hnRNP C. Insight into new research results
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In this article, we review the hottest oncogene HNRNPC, hoping to give you insights on its role in rare disease development as a therapeutic target in MCTD research.
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The NLRP3 gene encodes NLR Family Pyrin Domain Containing 3 - a pyrin-like protein which contains a pyrin domain, a nucleotide binding site (NBS) domain, and a leucine-rich repeat sequence (LRR) motif.
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The CAV1 gene is responsible for encoding the Caveolin 1 (CAV1) protein, also called caveolin-1 (CAV-1), which belongs to the Caveolin family of integral membrane proteins.
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Mutations in the excision and repair of cross-complementation group 6 (ERCC6) gene is known to result in Cockayne syndrome B (CSB), among some other disorders.
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Establishing appropriate animal models of disease is of vital importance in basic medical research – for which, rats and mice have become the animals of choice. However, rats are significantly superior to mice in many research areas, which strongly benefit from the larger size, superior cognition, and more human-like physiology, morphology, and genetics of rats. In this exclusive white paper, we review the research applications of rat models in Alzheimer's disease, oncology, and more.
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Entering this century, soon after the completion of the human genome project, the mouse genome was also completed. NIH embarked on the next endeavor to coordinate the knockout of every mouse gene and then study their phenotype systematically. These efforts have contributed enormously to the understanding of gene functions as well as genetic causes of human diseases.
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The recombination-activating genes, RAG1 & RAG2, play an essential role in lymphoid cell V(D)J recombination, which affects the production of highly diverse antibodies and T cell receptors (TCRs) in B and T cells. We review the background information, research insights, and applications of RAG1 & RAG2, hoping to provide helpful information for your scientific innovation.
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