With the development of research on the impact of immunity and inflammation on cancer, the performance of humanized mice attract tremendous attention in cancer clinical research.
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Mucopolysaccharidosis IVA (MPS IVA) - also known as Morquio Syndrome, type A - is inherited in an autosomal recessive manner and caused by mutations in the GALNS gene.
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In the previous article, we shared some diseases related to MARCHF2 (a.k.a. MARCH2). To this end, we introduce gene research' s next great example of this – Marchf2 knockout mice.
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The principle of CAR-T cell immunotherapy is to use genetic engineering methods to express chimeric antigen receptor (CAR) molecules on the surface of T cells.
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As of this year, there have been hundreds of recombinant adeno-associated virus (rAAV) gene therapy products approved to be marketed and entered into clinical trials worldwide. Why does AAV vector have such potential?
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To study the mechanisms that are largely unknown, researchers use gene knockout or down-regulation to regulate the expression of mouse Inpp5e gene.
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INPP5E (Inositol Polyphosphate-5-Phosphatase E) is a Protein Coding gene. Diseases associated with INPP5E include Joubert Syndrome 1 and Mental Retardation, Truncal Obesity, Retinal Dystrophy, and Micropenis (MORM) Syndrome.
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