Application of the Cre-Lox system is often used to achieve custom spatiotemporal operations on specific genes, which is useful for the study of gene function and animal models of human disease. Herein, we explore the Cre-Lox system and its profound impact on animal model construction capabilities.
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With the enhanced control of rat embryos and the use of CRISPR/Cas9 technology, the scope of applications for rats as experimental model animals in basic research, drug screenings, and preclinical drug evaluations has expanded.
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Establishing appropriate animal models of disease is of vital importance in basic medical research – for which, rats and mice have become the animals of choice. Mice are considered the most important model animal for analyzing human gene functions due to its small size, low operational costs, relatively stable embryonic cells, and pliability for various genetic manipulations and gene editing.
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The heterogenous nuclear ribonucleoprotein (hnRNP) family are multifunctional complexes of RNA and protein present in the cell nucleus that serve critical roles in gene regulation. Multiple lines of evidence have linked hnRNP abnormalities as key pathobiological drivers of cancer and neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
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The pneumonia-like COVID-19 caused by the novel coronavirus (SARS-CoV-2) remains a huge medical challenge worldwide. To provide a wholistic guide for developing clinical treatments, vaccines, and antiviral drugs, it is of great significance to study the interaction mechanisms between severe acute respiratory syndrome (SARS) coronaviruses and host molecules, while also exploring the pathogenic process of coronaviruses.
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From January through June of 2020, Cyagen received over 70 citations for our animal models, contributing to many advances across research fields. We have put together the below list of articles from high impact factor (IF) journals to provide insights into a variety of mouse model types, gene targets, research applications, and some of the most recent developments shown in scientific literature.
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The TurboKnockout® gene targeting service by Cyagen is based on traditional embryonic stem cell (ESC)-mediated targeting techniques, which can be used for complex gene knockout projects to provide C57BL/6 or (new) BALB/c mouse models with accurate genetic modification and no off-target effects.
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The COVID-19 epidemic is now a huge challenge for the entire world. Since the epidemic in most of the countries is controlled, colleges, universities and institutes worldwide, gradually returned to school or lab and started their scientific research work. However, the recent local restrictions and measures against COVID-19 and the unclear prospect of the epidemic have made many scientific researchers anxious.
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The following publications demonstrate the use of custom genetically modified mouse and rat models across a broad range of human disease studies, including immunological disorders, inflammatory disorders, cardiovascular disease, oncology, immunology, and liver disease.
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Despite the effects of COVID-19 on global business, we are operating at 100% proficiency - providing uninterrupted production and technical support to ensure that your research continues. We will continue serving your model generation, cloning, and virus packaging needs with the same high quality and fast turnaround as before the outbreak. Cyagen has established strong partnerships worldwide, improved our rigorous safety standards, and maintained full operational efficiency to ensure continuity in research operations for all our clients throughout this critical time.
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